InnateDB: Systems Biology of the Innate Immune Response

Homo sapiens Protein: UBE2D1

Summary

InnateDB Protein

IDBP-74937.6

Last Modified

2014-10-13 [Report errors or provide feedback]

Gene Symbol

UBE2D1

Protein Name

ubiquitin-conjugating enzyme E2D 1

Synonyms

E2(17)KB1; SFT; UBC4/5; UBCH5; UBCH5A;

Species

Homo sapiens

Ensembl Protein

ENSP00000363019

InnateDB Gene

IDBG-74933 (UBE2D1)

Protein Structure

UniProt Annotation

Function

Accepts ubiquitin from the E1 complex and catalyzes its covalent attachment to other proteins. In vitro catalyzes 'Lys- 48'-linked polyubiquitination. Mediates the selective degradation of short-lived and abnormal proteins. Functions in the E6/E6-AP- induced ubiquitination of p53/TP53. Mediates ubiquitination of PEX5 and auto-ubiquitination of STUB1, TRAF6 and TRIM63/MURF1. Ubiquitinates STUB1-associated HSP90AB1 in vitro. Lacks inherent specificity for any particular lysine residue of ubiquitin. Essential for viral activation of IRF3. Mediates polyubiquitination of CYP3A4. {ECO:0000269PubMed:18042044, ECO:0000269PubMed:18359941, ECO:0000269PubMed:19103148, ECO:0000269PubMed:19854139, ECO:0000269PubMed:20061386}.

Subcellular Localization

Cytoplasm {ECO:0000269PubMed:18845142}.

Disease Associations

Tissue Specificity

Ubiquitous. Up-regulated in livers of iron- overloaded patients with hereditary hemochromatosis. {ECO:0000269PubMed:12480712, ECO:0000269PubMed:9362508}.

Comments

Interactions

Number of Interactions

This gene and/or its encoded proteins are associated with 299 experimentally validated interaction(s) in this database.
They are also associated with 2 interaction(s) predicted by orthology.

Experimentally validated
Total	299 [view]
Protein-Protein	297 [view]
Protein-DNA	1 [view]
Protein-RNA	0
DNA-DNA	1 [view]
RNA-RNA	0
DNA-RNA	0

Predicted by orthology
Total	2 [view]

Gene Ontology

Molecular Function

Accession	GO Term
GO:0004842	ubiquitin-protein transferase activity
GO:0005515	protein binding
GO:0005524	ATP binding
GO:0016881	acid-amino acid ligase activity

Biological Process

GO:0000122	negative regulation of transcription from RNA polymerase II promoter
GO:0000209	protein polyubiquitination
GO:0000278	mitotic cell cycle
GO:0002224	toll-like receptor signaling pathway
GO:0002756	MyD88-independent toll-like receptor signaling pathway
GO:0006351	transcription, DNA-templated
GO:0006367	transcription initiation from RNA polymerase II promoter
GO:0006511	ubiquitin-dependent protein catabolic process
GO:0007094	mitotic spindle assembly checkpoint
GO:0007179	transforming growth factor beta receptor signaling pathway
GO:0010467	gene expression
GO:0030509	BMP signaling pathway
GO:0031145	anaphase-promoting complex-dependent proteasomal ubiquitin-dependent protein catabolic process
GO:0031398	positive regulation of protein ubiquitination
GO:0034138	toll-like receptor 3 signaling pathway
GO:0034142	toll-like receptor 4 signaling pathway
GO:0035666	TRIF-dependent toll-like receptor signaling pathway
GO:0045087	innate immune response
GO:0051436	negative regulation of ubiquitin-protein ligase activity involved in mitotic cell cycle
GO:0051437	positive regulation of ubiquitin-protein ligase activity involved in mitotic cell cycle
GO:0051439	regulation of ubiquitin-protein ligase activity involved in mitotic cell cycle
GO:0061418	regulation of transcription from RNA polymerase II promoter in response to hypoxia
GO:0070936	protein K48-linked ubiquitination
GO:0071456	cellular response to hypoxia