InnateDB: Systems Biology of the Innate Immune Response

Homo sapiens Protein: DYNC1I2

Summary

InnateDB Protein

IDBP-74951.7

Last Modified

2014-10-13 [Report errors or provide feedback]

Gene Symbol

DYNC1I2

Protein Name

dynein, cytoplasmic 1, intermediate chain 2

Synonyms

DNCI2; IC2;

Species

Homo sapiens

Ensembl Protein

ENSP00000339430

InnateDB Gene

IDBG-74949 (DYNC1I2)

Protein Structure

UniProt Annotation

Function

Acts as one of several non-catalytic accessory components of the cytoplasmic dynein 1 complex that are thought to be involved in linking dynein to cargos and to adapter proteins that regulate dynein function. Cytoplasmic dynein 1 acts as a motor for the intracellular retrograde motility of vesicles and organelles along microtubules. The intermediate chains mediate the binding of dynein to dynactin via its 150 kDa component (p150- glued) DCNT1. Involved in membrane-transport, such as Golgi apparatus, late endosomes and lysosomes.

Subcellular Localization

Cytoplasm, cytoskeleton {ECO:0000250}.

Disease Associations

Tissue Specificity

Comments

Interactions

Number of Interactions

This gene and/or its encoded proteins are associated with 38 experimentally validated interaction(s) in this database.

Experimentally validated
Total	38 [view]
Protein-Protein	38 [view]
Protein-DNA	0
Protein-RNA	0
DNA-DNA	0
RNA-RNA	0
DNA-RNA	0

Gene Ontology

Molecular Function

Accession	GO Term
GO:0003777	microtubule motor activity
GO:0005515	protein binding

Biological Process

GO:0000086	G2/M transition of mitotic cell cycle
GO:0000278	mitotic cell cycle
GO:0006810	transport
GO:0007018	microtubule-based movement
GO:0008152	metabolic process
GO:0016032	viral process
GO:0019886	antigen processing and presentation of exogenous peptide antigen via MHC class II