Version 5.4
Homo sapiens Protein: TFAM
Summary
InnateDB Protein IDBP-74969.6
Last Modified 2014-10-13 [Report errors or provide feedback]
Gene Symbol TFAM
Protein Name transcription factor A, mitochondrial
Synonyms MTTF1; MTTFA; TCF6; TCF6L1; TCF6L2; TCF6L3;
Species Homo sapiens
Ensembl Protein ENSP00000363002
InnateDB Gene IDBG-74965 (TFAM)
Protein Structure
UniProt Annotation
Function
Subcellular Localization
Disease Associations
Tissue Specificity
Comments
Interactions
Number of Interactions This gene and/or its encoded proteins are associated with 20 experimentally validated interaction(s) in this database.
Experimentally validated
Total 20 [view]
Protein-Protein 19 [view]
Protein-DNA 1 [view]
Protein-RNA 0
DNA-DNA 0
RNA-RNA 0
DNA-RNA 0
Gene Ontology

Molecular Function
Accession GO Term
GO:0003682 chromatin binding
GO:0003700 sequence-specific DNA binding transcription factor activity
GO:0005515 protein binding
GO:0008301 DNA binding, bending
GO:0044822 poly(A) RNA binding
GO:0070363 mitochondrial light strand promoter sense binding
Biological Process
GO:0006261 DNA-dependent DNA replication
GO:0006356 regulation of transcription from RNA polymerase I promoter
GO:0006390 transcription from mitochondrial promoter
GO:0006391 transcription initiation from mitochondrial promoter
GO:0010467 gene expression
GO:0045893 positive regulation of transcription, DNA-templated
Cellular Component
GO:0005634 nucleus
GO:0005739 mitochondrion
GO:0005759 mitochondrial matrix
GO:0042645 mitochondrial nucleoid
Protein Structure and Domains
PDB ID
InterPro IPR009071 High mobility group box domain
PFAM PF00505
PF09011
PRINTS
PIRSF
SMART SM00398
TIGRFAMs
Post-translational Modifications
Modification
Cross-References
SwissProt Q00059
PhosphoSite PhosphoSite-Q00059
TrEMBL
UniProt Splice Variant
Entrez Gene 7019
UniGene
RefSeq NP_001257711
HUGO HGNC:11741
OMIM 600438
CCDS CCDS59217
HPRD 02702
IMGT
EMBL AB451241 AB451366 AC023170 AK312558 BC126366 BT019658 BT019659 EU279428 M62810 X64269
GenPept AAA59849 AAI26367 AAV38464 AAV38465 ABX72056 BAG35455 BAG70055 BAG70180 CAA45562

If you use InnateDB for your research, please cite the following publication:

Breuer et al., InnateDB: systems biology of innate immunity and beyond - recent updates and continuing curation. Nucl. Acids Res. (2013) 41 (D1) 

InnateDB is being developed jointly by the Brinkman Laboratory (Simon Fraser University, British Columbia, Canada), the Hancock Laboratory (University of British Columbia, Vancouver, British Columbia) and the Lynn EMBL Australia Group (South Australian Health & Medical Research Institute and Flinders University, Adelaide, Australia).

Funding is currently provided by Allergen and EMBL Australia. Previous funding has been provided by Genome Canada, the Foundation for the National Institutes of Health through the Grand Challenges in Global Health initiative and by Teagasc. InnateDB curated interactions are licensed under the Design Science License. All other data is licensed under the terms of the originating database. Contact: innatedb-mail@sfu.ca