InnateDB: Systems Biology of the Innate Immune Response

Homo sapiens Protein: CTSL1

Summary

InnateDB Protein

IDBP-74985.6

Last Modified

2014-10-13 [Report errors or provide feedback]

Gene Symbol

CTSL1

Protein Name

cathepsin L1

Synonyms

CATL; CTSL1; MEP;

Species

Homo sapiens

Ensembl Protein

ENSP00000365061

InnateDB Gene

IDBG-74981 (CTSL1)

Protein Structure

UniProt Annotation

Function

Important for the overall degradation of proteins in lysosomes.

Subcellular Localization

Lysosome.

Disease Associations

Tissue Specificity

Comments

Interactions

Number of Interactions

This gene and/or its encoded proteins are associated with 18 experimentally validated interaction(s) in this database.

Gene Ontology

Molecular Function

Accession	GO Term
GO:0001968	fibronectin binding
GO:0004197	cysteine-type endopeptidase activity
GO:0005515	protein binding
GO:0005518	collagen binding
GO:0008234	cysteine-type peptidase activity
GO:0042393	histone binding
GO:0043394	proteoglycan binding

Biological Process

GO:0002224	toll-like receptor signaling pathway
GO:0002250	adaptive immune response
GO:0006508	proteolysis
GO:0019882	antigen processing and presentation
GO:0019886	antigen processing and presentation of exogenous peptide antigen via MHC class II
GO:0022617	extracellular matrix disassembly
GO:0030198	extracellular matrix organization
GO:0030574	collagen catabolic process
GO:0045087	innate immune response (InnateDB)
GO:0051603	proteolysis involved in cellular protein catabolic process
GO:0071888	macrophage apoptotic process
GO:0097067	cellular response to thyroid hormone stimulus

Cellular Component

GO:0005576	extracellular region
GO:0005615	extracellular space
GO:0005634	nucleus
GO:0005764	lysosome
GO:0036021	endolysosome lumen
GO:0043202	lysosomal lumen
GO:0070062	extracellular vesicular exosome