InnateDB: Systems Biology of the Innate Immune Response

Homo sapiens Protein: ZP2

Summary

InnateDB Protein

IDBP-750997.3

Last Modified

2014-10-13 [Report errors or provide feedback]

Gene Symbol

ZP2

Protein Name

Synonyms

Zp-2; ZPA;

Species

Homo sapiens

Ensembl Protein

ENSP00000460971

InnateDB Gene

IDBG-19031 (ZP2)

Protein Structure

UniProt Annotation

Function

The mammalian zona pellucida, which mediates species- specific sperm binding, induction of the acrosome reaction and prevents post-fertilization polyspermy, is composed of three to four glycoproteins, ZP1, ZP2, ZP3, and ZP4. ZP2 may act as a secondary sperm receptor.

Subcellular Localization

Processed zona pellucida sperm-binding protein 2: Secreted, extracellular space, extracellular matrix. Note=The glycoproteinaceous translucent extracellular matrix that surrounds the mammalian oocyte is called zona pellucida.Cell membrane; Single-pass type I membrane protein.

Disease Associations

Tissue Specificity

Oocytes.

Comments

Interactions

Number of Interactions

This gene and/or its encoded proteins are associated with 1 experimentally validated interaction(s) in this database.
They are also associated with 1 interaction(s) predicted by orthology.

Experimentally validated
Total	1 [view]
Protein-Protein	1 [view]
Protein-DNA	0
Protein-RNA	0
DNA-DNA	0
RNA-RNA	0
DNA-RNA	0

Predicted by orthology
Total	1 [view]

Gene Ontology

Molecular Function

Accession	GO Term
GO:0005515	protein binding
GO:0015026	coreceptor activity
GO:0032190	acrosin binding

Biological Process

GO:0006886	intracellular protein transport
GO:0007165	signal transduction
GO:0007338	single fertilization
GO:0007339	binding of sperm to zona pellucida
GO:0032504	multicellular organism reproduction
GO:0060468	prevention of polyspermy

Cellular Component

GO:0005576	extracellular region
GO:0005578	proteinaceous extracellular matrix
GO:0005771	multivesicular body
GO:0005783	endoplasmic reticulum
GO:0005794	Golgi apparatus
GO:0005886	plasma membrane
GO:0016021	integral component of membrane
GO:0030141	secretory granule
GO:0031012	extracellular matrix