InnateDB: Systems Biology of the Innate Immune Response

Homo sapiens Gene: ZP2

Summary

InnateDB Gene

IDBG-19031.6

Last Modified

2014-10-13 [Report errors or provide feedback]

Gene Symbol

ZP2

Gene Name

zona pellucida glycoprotein 2 (sperm receptor)

Synonyms

Zp-2; ZPA

Species

Homo sapiens

Ensembl Gene

ENSG00000103310

Encoded Proteins

IDBP-746269

IDBP-750997

Protein Structure

Useful resources

Stemformatics EHFPI ImmGen

Entrez Gene

Summary

The zona pellucida is an extracellular matrix that surrounds the oocyte and early embryo. It is composed primarily of three or four glycoproteins with various functions during fertilization and preimplantation development. The protein encoded by this gene is a structural component of the zona pellucida and functions in secondary binding and penetration of acrosome-reacted spermatozoa. The nascent protein contains a N-terminal signal peptide sequence, a conserved ZP domain, a consensus furin cleavage site, and a C-terminal transmembrane domain. It is hypothesized that furin cleavage results in release of the mature protein from the plasma membrane for subsequent incorporation into the zona pellucida matrix. However, the requirement for furin cleavage in this process remains controversial based on mouse studies. [provided by RefSeq, Jul 2008]
The zona pellucida is an extracellular matrix that surrounds the oocyte and early embryo. It is composed of three glycoproteins with various functions during fertilization and preimplantation development. The glycosylated mature peptide is one of the structural components of the zona pellucida and functions in secondary binding and penetration of acrosome-reacted spermatozoa. Female mice lacking this gene do not form a stable zona matrix and are sterile. Alternative splicing results in multiple transcript variants. [provided by RefSeq, Feb 2014]

Gene Information

Type

Protein coding

Genomic Location

Chromosome 16:21197450-21214510

Strand

Reverse strand

Band

p12.2

Transcripts

ENST00000572752
ENST00000573114
ENST00000574091	ENSP00000458991
ENST00000576162
ENST00000574002	ENSP00000460971

Interactions

Number of Interactions

This gene and/or its encoded proteins are associated with 1 experimentally validated interaction(s) in this database.
They are also associated with 1 interaction(s) predicted by orthology.

Experimentally validated
Total	1 [view]
Protein-Protein	1 [view]
Protein-DNA	0
Protein-RNA	0
DNA-DNA	0
RNA-RNA	0
DNA-RNA	0

Predicted by orthology
Total	1 [view]

Gene Ontology

Molecular Function

Accession	GO Term
GO:0005515	protein binding
GO:0015026	coreceptor activity
GO:0032190	acrosin binding

Biological Process

GO:0006886	intracellular protein transport
GO:0007165	signal transduction
GO:0007338	single fertilization
GO:0007339	binding of sperm to zona pellucida
GO:0032504	multicellular organism reproduction
GO:0060468	prevention of polyspermy

Cellular Component

GO:0005576	extracellular region
GO:0005578	proteinaceous extracellular matrix
GO:0005771	multivesicular body
GO:0005783	endoplasmic reticulum
GO:0005794	Golgi apparatus
GO:0005886	plasma membrane
GO:0016021	integral component of membrane
GO:0030141	secretory granule
GO:0031012	extracellular matrix

Orthologs

Species

Mus musculus

Bos taurus

Gene ID

Gene Order

ENSMUSG00000030911

View Gene Order

ENSBTAG00000011504

Not yet available

Pathways

NETPATH

REACTOME

REACT_163933

Interaction With The Zona Pellucida pathway

REACT_163914

Fertilization pathway

REACT_163848

Reproduction pathway

KEGG

INOH

PID NCI

Cross-References

SwissProt

TrEMBL

UniProt Splice Variant

Entrez Gene

UniGene

Hs.73982 Hs.740134

RefSeq

NM_001290104 NM_003460 XM_005255562 XM_006721090

HUGO

OMIM

CCDS

CCDS10596 CCDS73843

HPRD

01689

IMGT

EMBL

GenPept

RNA Seq Atlas