Version 5.4
Homo sapiens Protein: DOC2A
Summary
InnateDB Protein IDBP-751166.3
Last Modified 2014-10-13 [Report errors or provide feedback]
Gene Symbol DOC2A
Protein Name
Synonyms Doc2;
Species Homo sapiens
Ensembl Protein ENSP00000455196
InnateDB Gene IDBG-25372 (DOC2A)
Protein Structure
UniProt Annotation
Function Calcium sensor which most probably regulates fusion of vesicles with membranes. Binds calcium and phospholipids. May be involved in calcium dependent neurotransmitter release through the interaction with UNC13A. May be involved in calcium-dependent spontaneous release of neurotransmitter in absence of action potentials in neuronal cells. Regulates Ca(2+)-dependent secretory lysosome exocytosis in mast cells. {ECO:0000269PubMed:18354201, ECO:0000269PubMed:9736751, ECO:0000269PubMed:9804756}.
Subcellular Localization Lysosome {ECO:0000250}. Cytoplasmic vesicle, secretory vesicle, synaptic vesicle membrane {ECO:0000305}; Peripheral membrane protein {ECO:0000305}. Cell junction, synapse, synaptosome. Note=Colocalizes to synaptic vesicles.
Disease Associations
Tissue Specificity Predominantly expressed in brain. Also expressed in testis. {ECO:0000269PubMed:7826360, ECO:0000269PubMed:8554557}.
Comments
Interactions
Number of Interactions This gene and/or its encoded proteins are associated with 4 experimentally validated interaction(s) in this database.
Experimentally validated
Total 4 [view]
Protein-Protein 4 [view]
Protein-DNA 0
Protein-RNA 0
DNA-DNA 0
RNA-RNA 0
DNA-RNA 0
Gene Ontology

Molecular Function
Accession GO Term
GO:0005215 transporter activity
GO:0005515 protein binding
GO:0005544 calcium-dependent phospholipid binding
Biological Process
GO:0007268 synaptic transmission
GO:0007399 nervous system development
GO:0017158 regulation of calcium ion-dependent exocytosis
Cellular Component
GO:0005764 lysosome
GO:0030054 cell junction
GO:0030672 synaptic vesicle membrane
GO:0043005 neuron projection
Protein Structure and Domains
PDB ID
InterPro IPR000008 C2 domain
IPR001565 Synaptotagmin
IPR014638 Double C2 protein, alpha/beta/gamma type
PFAM PF00168
PRINTS PR00360
PR00399
PIRSF PIRSF036931
SMART SM00239
TIGRFAMs
Post-translational Modifications
Modification
Cross-References
SwissProt Q14183
PhosphoSite PhosphoSite-Q14183
TrEMBL H3BU41
UniProt Splice Variant
Entrez Gene 8448
UniGene Hs.733294
RefSeq XP_006721162
HUGO HGNC:2985
OMIM 604567
CCDS CCDS10666
HPRD 05195
IMGT
EMBL AC093512 BC041769 BC055284 BC063436 D31897
GenPept AAH41769 AAH55284 AAH63436 BAA06695

If you use InnateDB for your research, please cite the following publication:

Breuer et al., InnateDB: systems biology of innate immunity and beyond - recent updates and continuing curation. Nucl. Acids Res. (2013) 41 (D1) 

InnateDB is being developed jointly by the Brinkman Laboratory (Simon Fraser University, British Columbia, Canada), the Hancock Laboratory (University of British Columbia, Vancouver, British Columbia) and the Lynn EMBL Australia Group (South Australian Health & Medical Research Institute and Flinders University, Adelaide, Australia).

Funding is currently provided by Allergen and EMBL Australia. Previous funding has been provided by Genome Canada, the Foundation for the National Institutes of Health through the Grand Challenges in Global Health initiative and by Teagasc. InnateDB curated interactions are licensed under the Design Science License. All other data is licensed under the terms of the originating database. Contact: innatedb-mail@sfu.ca