Version 5.4
Homo sapiens Protein: EME2
Summary
InnateDB Protein IDBP-751527.3
Last Modified 2014-10-13 [Report errors or provide feedback]
Gene Symbol EME2
Protein Name
Synonyms
Species Homo sapiens
Ensembl Protein ENSP00000457353
InnateDB Gene IDBG-9284 (EME2)
Protein Structure
UniProt Annotation
Function Interacts with MUS81 to form a DNA structure-specific endonuclease which cleaves substrates such as 3'-flap structures. {ECO:0000269PubMed:17289582}.
Subcellular Localization Nucleus {ECO:0000305}.
Disease Associations
Tissue Specificity
Comments
Interactions
Number of Interactions This gene and/or its encoded proteins are associated with 4 experimentally validated interaction(s) in this database.
Experimentally validated
Total 4 [view]
Protein-Protein 4 [view]
Protein-DNA 0
Protein-RNA 0
DNA-DNA 0
RNA-RNA 0
DNA-RNA 0
Gene Ontology

Molecular Function
Accession GO Term
GO:0003677 DNA binding
GO:0004518 nuclease activity
GO:0004519 endonuclease activity
Biological Process
GO:0006281 DNA repair
GO:0006310 DNA recombination
GO:0090305 nucleic acid phosphodiester bond hydrolysis
Cellular Component
GO:0005634 nucleus
Protein Structure and Domains
PDB ID
InterPro IPR006166 ERCC4 domain
PFAM PF02732
PRINTS
PIRSF
SMART SM00891
TIGRFAMs
Post-translational Modifications
Modification
Cross-References
SwissProt A4GXA9
PhosphoSite PhosphoSite-
TrEMBL
UniProt Splice Variant
Entrez Gene 197342
UniGene Hs.731950
RefSeq NP_001244299
HUGO HGNC:27289
OMIM 610886
CCDS CCDS58404
HPRD 16859
IMGT
EMBL AE006639 AK074080 EF452422
GenPept AAK61292 ABO21766 BAB84906

If you use InnateDB for your research, please cite the following publication:

Breuer et al., InnateDB: systems biology of innate immunity and beyond - recent updates and continuing curation. Nucl. Acids Res. (2013) 41 (D1) 

InnateDB is being developed jointly by the Brinkman Laboratory (Simon Fraser University, British Columbia, Canada), the Hancock Laboratory (University of British Columbia, Vancouver, British Columbia) and the Lynn EMBL Australia Group (South Australian Health & Medical Research Institute and Flinders University, Adelaide, Australia).

Funding is currently provided by Allergen and EMBL Australia. Previous funding has been provided by Genome Canada, the Foundation for the National Institutes of Health through the Grand Challenges in Global Health initiative and by Teagasc. InnateDB curated interactions are licensed under the Design Science License. All other data is licensed under the terms of the originating database. Contact: innatedb-mail@sfu.ca