Homo sapiens Protein: RFWD3 | |||||||||||||||||||
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Summary | |||||||||||||||||||
InnateDB Protein | IDBP-751535.3 | ||||||||||||||||||
Last Modified | 2014-10-13 [Report errors or provide feedback] | ||||||||||||||||||
Gene Symbol | RFWD3 | ||||||||||||||||||
Protein Name | |||||||||||||||||||
Synonyms | |||||||||||||||||||
Species | Homo sapiens | ||||||||||||||||||
Ensembl Protein | ENSP00000460049 | ||||||||||||||||||
InnateDB Gene | IDBG-42109 (RFWD3) | ||||||||||||||||||
Protein Structure | |||||||||||||||||||
UniProt Annotation | |||||||||||||||||||
Function | E3 ubiquitin-protein ligase that mediates the ubiquitination of p53/TP53 in the late response to DNA damage, and acts as a positive regulator of p53/TP53 stability, thereby regulating the G1/S DNA damage checkpoint. May act by catalyzing the formation of short polyubiquitin chains on p53/TP53 that are not targeted to the proteasome. In response to ionizing radiation, interacts with MDM2 and enhances p53/TP53 ubiquitination, possibly by restricting MDM2 from extending polyubiquitin chains on ubiquitinated p53/TP53. Plays a role in RPA-mediated DNA damage signaling and repair. {ECO:0000269PubMed:20173098, ECO:0000269PubMed:21504906, ECO:0000269PubMed:21558276}. | ||||||||||||||||||
Subcellular Localization | Nucleus. Nucleus, PML body. Cytoplasm. Note=In undamaged cells, found both in the cytoplasm and in the nucleus, partially associated with PML nuclear bodies. In response to replication block, such as that caused by hydroxyurea treatment, or to DNA damage caused by ionizing radiations or doxorubicin, recruited to the nucleus, to stalled replication forks or to sites of DNA repair. This recruitment depends upon RPA2. | ||||||||||||||||||
Disease Associations | |||||||||||||||||||
Tissue Specificity | |||||||||||||||||||
Comments | |||||||||||||||||||
Interactions | |||||||||||||||||||
Number of Interactions |
This gene and/or its encoded proteins are associated with 26 experimentally validated interaction(s) in this database.
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Gene Ontology | |||||||||||||||||||
Molecular Function |
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Biological Process |
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Cellular Component |
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Protein Structure and Domains | |||||||||||||||||||
PDB ID | |||||||||||||||||||
InterPro |
IPR001680
WD40 repeat IPR001841 Zinc finger, RING-type IPR018957 Zinc finger, C3HC4 RING-type |
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PFAM |
PF00400
PF13639 PF14634 PF00097 |
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PRINTS | |||||||||||||||||||
PIRSF | |||||||||||||||||||
SMART |
SM00320
SM00184 |
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TIGRFAMs | |||||||||||||||||||
Post-translational Modifications | |||||||||||||||||||
Modification | |||||||||||||||||||
Cross-References | |||||||||||||||||||
SwissProt | Q6PCD5 | ||||||||||||||||||
PhosphoSite | PhosphoSite-Q6PCD5 | ||||||||||||||||||
TrEMBL | I3L4I5 | ||||||||||||||||||
UniProt Splice Variant | |||||||||||||||||||
Entrez Gene | 55159 | ||||||||||||||||||
UniGene | Hs.567525 | ||||||||||||||||||
RefSeq | |||||||||||||||||||
HUGO | HGNC:25539 | ||||||||||||||||||
OMIM | 614151 | ||||||||||||||||||
CCDS | CCDS32486 | ||||||||||||||||||
HPRD | 07678 | ||||||||||||||||||
IMGT | |||||||||||||||||||
EMBL | AC109599 AK001382 AK022673 AK291200 AK315786 BC002574 BC059371 CH471114 | ||||||||||||||||||
GenPept | AAH02574 AAH59371 BAA91662 BAB14169 BAF83889 BAG38132 EAW95680 EAW95681 | ||||||||||||||||||