InnateDB: Systems Biology of the Innate Immune Response

Homo sapiens Protein: PDK1

Summary

InnateDB Protein

IDBP-75176.6

Last Modified

2014-10-13 [Report errors or provide feedback]

Gene Symbol

PDK1

Protein Name

pyruvate dehydrogenase kinase, isozyme 1

Synonyms

Species

Homo sapiens

Ensembl Protein

ENSP00000282077

InnateDB Gene

IDBG-75174 (PDK1)

Protein Structure

UniProt Annotation

Function

Serine/threonine kinase that plays a key role in regulation of glucose and fatty acid metabolism and homeostasis via phosphorylation of the pyruvate dehydrogenase subunits PDHA1 and PDHA2. This inhibits pyruvate dehydrogenase activity, and thereby regulates metabolite flux through the tricarboxylic acid cycle, down-regulates aerobic respiration and inhibits the formation of acetyl-coenzyme A from pyruvate. Plays an important role in cellular responses to hypoxia and is important for cell proliferation under hypoxia. Protects cells against apoptosis in response to hypoxia and oxidative stress. {ECO:0000269PubMed:17683942, ECO:0000269PubMed:18541534, ECO:0000269PubMed:22195962, ECO:0000269PubMed:7499431}.

Subcellular Localization

Mitochondrion matrix {ECO:0000269PubMed:22195962}.

Disease Associations

Tissue Specificity

Expressed predominantly in the heart. Detected at lower levels in liver, skeletal muscle and pancreas. {ECO:0000269PubMed:7499431}.

Comments

Interactions

Number of Interactions

This gene and/or its encoded proteins are associated with 39 experimentally validated interaction(s) in this database.

Experimentally validated
Total	39 [view]
Protein-Protein	34 [view]
Protein-DNA	2 [view]
Protein-RNA	0
DNA-DNA	3 [view]
RNA-RNA	0
DNA-RNA	0

Gene Ontology

Molecular Function

Accession	GO Term
GO:0004672	protein kinase activity
GO:0004674	protein serine/threonine kinase activity
GO:0004740	pyruvate dehydrogenase (acetyl-transferring) kinase activity
GO:0005515	protein binding
GO:0005524	ATP binding
GO:0016301	kinase activity

Biological Process

GO:0006006	glucose metabolic process
GO:0006090	pyruvate metabolic process
GO:0006468	protein phosphorylation
GO:0008283	cell proliferation
GO:0008631	intrinsic apoptotic signaling pathway in response to oxidative stress
GO:0010510	regulation of acetyl-CoA biosynthetic process from pyruvate
GO:0010906	regulation of glucose metabolic process
GO:0016310	phosphorylation
GO:0044237	cellular metabolic process
GO:0044281	small molecule metabolic process
GO:0097411	hypoxia-inducible factor-1alpha signaling pathway

Cellular Component

GO:0005739	mitochondrion
GO:0005759	mitochondrial matrix

Protein Structure and Domains

PDB ID

InterPro

IPR003594 Histidine kinase-like ATPase, C-terminal domain
IPR005467 Signal transduction histidine kinase, core
IPR018955 Branched-chain alpha-ketoacid dehydrogenase kinase/Pyruvate dehydrogenase kinase, N-terminal

PFAM

PF02518
PF13581
PF10436

PRINTS

PIRSF

SMART

SM00387

TIGRFAMs

Post-translational Modifications

Modification

Cross-References

SwissProt

Q15118