InnateDB: Systems Biology of the Innate Immune Response

Homo sapiens Protein: KIFC3

Summary

InnateDB Protein

IDBP-752035.3

Last Modified

2014-10-13 [Report errors or provide feedback]

Gene Symbol

KIFC3

Protein Name

Synonyms

Species

Homo sapiens

Ensembl Protein

ENSP00000456239

InnateDB Gene

IDBG-33815 (KIFC3)

Protein Structure

UniProt Annotation

Function

Minus-end microtubule-dependent motor protein. Involved in apically targeted transport (By similarity). Required for zonula adherens maintenance. {ECO:0000250, ECO:0000269PubMed:19041755}.

Subcellular Localization

Cell junction, adherens junction {ECO:0000269PubMed:19041755}. Cytoplasm, cytoskeleton, microtubule organizing center, centrosome {ECO:0000269PubMed:19041755}. Cytoplasmic vesicle membrane {ECO:0000250}; Peripheral membrane protein {ECO:0000250}. Note=Apical cell membrane. On membrane organelles immediately beneath the apical plasma membrane of renal tubular epithelial cells. Localized in the distal tubules and loops of Henle in the kidney, but not in the proximal tubules or the glomeruli, with stronger staining in the apical area of these epithelial cells (By similarity). Localizes along zonula adherens only at mature cell- cell contacts. {ECO:0000250}.

Disease Associations

Tissue Specificity

Comments

Interactions

Number of Interactions

This gene and/or its encoded proteins are associated with 25 experimentally validated interaction(s) in this database.
They are also associated with 1 interaction(s) predicted by orthology.

Experimentally validated
Total	25 [view]
Protein-Protein	25 [view]
Protein-DNA	0
Protein-RNA	0
DNA-DNA	0
RNA-RNA	0
DNA-RNA	0

Predicted by orthology
Total	1 [view]

Gene Ontology

Molecular Function

Accession	GO Term
GO:0003777	microtubule motor activity
GO:0005524	ATP binding
GO:0008017	microtubule binding

Biological Process

GO:0007018	microtubule-based movement
GO:0007601	visual perception
GO:0008152	metabolic process
GO:0045218	zonula adherens maintenance
GO:0090136	epithelial cell-cell adhesion