InnateDB: Systems Biology of the Innate Immune Response

Homo sapiens Protein: ROBO4

Summary

InnateDB Protein

IDBP-75301.6

Last Modified

2014-10-13 [Report errors or provide feedback]

Gene Symbol

ROBO4

Protein Name

roundabout homolog 4, magic roundabout (Drosophila)

Synonyms

Species

Homo sapiens

Ensembl Protein

ENSP00000304945

InnateDB Gene

IDBG-75299 (ROBO4)

Protein Structure

UniProt Annotation

Function

Receptor for Slit proteins, at least for SLIT2, and seems to be involved in angiogenesis and vascular patterning. May mediate the inhibition of primary endothelial cell migration by Slit proteins (By similarity). {ECO:0000250}.

Subcellular Localization

Disease Associations

Tissue Specificity

Specifically expressed in endothelial cells. Expressed at sites of angiogenesis in different tumor types. {ECO:0000269PubMed:11944987}.

Comments

Interactions

Number of Interactions

This gene and/or its encoded proteins are associated with 4 experimentally validated interaction(s) in this database.
They are also associated with 1 interaction(s) predicted by orthology.

Experimentally validated
Total	4 [view]
Protein-Protein	4 [view]
Protein-DNA	0
Protein-RNA	0
DNA-DNA	0
RNA-RNA	0
DNA-RNA	0

Predicted by orthology
Total	1 [view]

Gene Ontology

Molecular Function

Accession	GO Term
GO:0004872	receptor activity
GO:0005515	protein binding

Biological Process

GO:0001525	angiogenesis
GO:0030154	cell differentiation
GO:0030334	regulation of cell migration
GO:0030336	negative regulation of cell migration

Cellular Component

GO:0009897	external side of plasma membrane
GO:0016021	integral component of membrane
GO:0070062	extracellular vesicular exosome

Protein Structure and Domains

PDB ID

InterPro

IPR003598 Immunoglobulin subtype 2
IPR003599 Immunoglobulin subtype
IPR003961 Fibronectin, type III
IPR007110 Immunoglobulin-like domain
IPR013098 Immunoglobulin I-set
IPR013151 Immunoglobulin

PFAM

PF00041
PF01108
PF07679
PF00047

PRINTS

PIRSF

SMART

SM00408
SM00409
SM00060

TIGRFAMs

Post-translational Modifications

Modification

Cross-References

SwissProt

Q8WZ75