Version 5.4
Homo sapiens Protein: SLC6A2
Summary
InnateDB Protein IDBP-753083.3
Last Modified 2014-10-13 [Report errors or provide feedback]
Gene Symbol SLC6A2
Protein Name
Synonyms NAT1; NET; NET1; SLC6A5;
Species Homo sapiens
Ensembl Protein ENSP00000457473
InnateDB Gene IDBG-31382 (SLC6A2)
Protein Structure
UniProt Annotation
Function Amine transporter. Terminates the action of noradrenaline by its high affinity sodium-dependent reuptake into presynaptic terminals.
Subcellular Localization Membrane; Multi-pass membrane protein.
Disease Associations Orthostatic intolerance (OI) [MIM:604715]: Syndrome characterized by lightheadedness, fatigue, altered mentation and syncope. It is associated with postural tachycardia. Plasma norepinephrine concentration is abnormally high. {ECO:0000269PubMed:10684912}. Note=The disease is caused by mutations affecting the gene represented in this entry.
Tissue Specificity
Comments
Interactions
Number of Interactions This gene and/or its encoded proteins are associated with 5 experimentally validated interaction(s) in this database.
Experimentally validated
Total 5 [view]
Protein-Protein 4 [view]
Protein-DNA 1 [view]
Protein-RNA 0
DNA-DNA 0
RNA-RNA 0
DNA-RNA 0
Gene Ontology

Molecular Function
Accession GO Term
GO:0005328 neurotransmitter:sodium symporter activity
GO:0005334 norepinephrine:sodium symporter activity
GO:0005515 protein binding
GO:0008504 monoamine transmembrane transporter activity
Biological Process
GO:0006810 transport
GO:0006836 neurotransmitter transport
GO:0007268 synaptic transmission
GO:0015844 monoamine transport
GO:0055085 transmembrane transport
Cellular Component
GO:0005886 plasma membrane
GO:0005887 integral component of plasma membrane
GO:0016020 membrane
GO:0016021 integral component of membrane
Protein Structure and Domains
PDB ID
InterPro IPR000175 Sodium:neurotransmitter symporter
IPR002435 Sodium:neurotransmitter symporter, noradrenaline
PFAM PF00209
PRINTS PR00176
PR01201
PIRSF
SMART
TIGRFAMs
Post-translational Modifications
Modification
Cross-References
SwissProt P23975
PhosphoSite PhosphoSite-P23975
TrEMBL Q9UQ04
UniProt Splice Variant
Entrez Gene 6530
UniGene Hs.78036
RefSeq NP_001165972
HUGO HGNC:11048
OMIM 163970
CCDS CCDS10754
HPRD 01232
IMGT
EMBL AB022846 AC136621 AK301811 AK312793 CH471092 M65105 X91117 X91118 X91119 X91120 X91121 X91122 X91123 X91124 X91125 X91126 X91127
GenPept AAA59943 BAA82110 BAG35654 BAG63260 CAA62566 CAC39181 EAW82831 EAW82833 EAW82834 EAW82835

If you use InnateDB for your research, please cite the following publication:

Breuer et al., InnateDB: systems biology of innate immunity and beyond - recent updates and continuing curation. Nucl. Acids Res. (2013) 41 (D1) 

InnateDB is being developed jointly by the Brinkman Laboratory (Simon Fraser University, British Columbia, Canada), the Hancock Laboratory (University of British Columbia, Vancouver, British Columbia) and the Lynn EMBL Australia Group (South Australian Health & Medical Research Institute and Flinders University, Adelaide, Australia).

Funding is currently provided by Allergen and EMBL Australia. Previous funding has been provided by Genome Canada, the Foundation for the National Institutes of Health through the Grand Challenges in Global Health initiative and by Teagasc. InnateDB curated interactions are licensed under the Design Science License. All other data is licensed under the terms of the originating database. Contact: innatedb-mail@sfu.ca