InnateDB: Systems Biology of the Innate Immune Response

Homo sapiens Gene: SLC6A2

Summary

InnateDB Gene

IDBG-31382.6

Last Modified

2014-10-13 [Report errors or provide feedback]

Gene Symbol

SLC6A2

Gene Name

solute carrier family 6 (neurotransmitter transporter, noradrenalin), member 2

Synonyms

NAT1; NET; NET1; SLC6A5

Species

Homo sapiens

Ensembl Gene

ENSG00000103546

Encoded Proteins

IDBP-31384

solute carrier family 6 (neurotransmitter transporter, noradrenalin), member 2

IDBP-31386

solute carrier family 6 (neurotransmitter transporter, noradrenalin), member 2

IDBP-377155

solute carrier family 6 (neurotransmitter transporter, noradrenalin), member 2

IDBP-753083

IDBP-752097

IDBP-746849

IDBP-745595

IDBP-748257

IDBP-753479

IDBP-751867

Protein Structure

Useful resources

Stemformatics EHFPI ImmGen

Entrez Gene

Summary

This gene encodes a member of the sodium:neurotransmitter symporter family. This member is a multi-pass membrane protein, which is responsible for reuptake of norepinephrine into presynaptic nerve terminals and is a regulator of norepinephrine homeostasis. Mutations in this gene cause orthostatic intolerance, a syndrome characterized by lightheadedness, fatigue, altered mentation and syncope. Alternatively spliced transcript variants encoding different isoforms have been identified in this gene.[provided by RefSeq, Feb 2010]

Gene Information

Type

Protein coding

Genomic Location

Chromosome 16:55655604-55706192

Strand

Forward strand

Band

q12.2

Transcripts

ENST00000219833	ENSP00000219833
ENST00000379906	ENSP00000369237
ENST00000414754	ENSP00000394956
ENST00000568943	ENSP00000457473
ENST00000567238	ENSP00000457375
ENST00000568529	ENSP00000456377
ENST00000566163	ENSP00000456210
ENST00000561820	ENSP00000454439
ENST00000574918	ENSP00000460214
ENST00000568655	ENSP00000454603

Interactions

Number of Interactions

This gene and/or its encoded proteins are associated with 5 experimentally validated interaction(s) in this database.

Experimentally validated
Total	5 [view]
Protein-Protein	4 [view]
Protein-DNA	1 [view]
Protein-RNA	0
DNA-DNA	0
RNA-RNA	0
DNA-RNA	0

Gene Ontology

Molecular Function

Accession	GO Term
GO:0005328	neurotransmitter:sodium symporter activity
GO:0005333	norepinephrine transmembrane transporter activity
GO:0005334	norepinephrine:sodium symporter activity
GO:0005515	protein binding
GO:0008504	monoamine transmembrane transporter activity
GO:0043014	alpha-tubulin binding
GO:0048487	beta-tubulin binding

Biological Process

GO:0006810	transport
GO:0006836	neurotransmitter transport
GO:0007268	synaptic transmission
GO:0015844	monoamine transport
GO:0015874	norepinephrine transport
GO:0042493	response to drug
GO:0048265	response to pain
GO:0055085	transmembrane transport

Cellular Component

GO:0005886	plasma membrane
GO:0005887	integral component of plasma membrane
GO:0009986	cell surface
GO:0016020	membrane
GO:0016021	integral component of membrane
GO:0043005	neuron projection
GO:0045121	membrane raft

Orthologs

Species

Mus musculus

Bos taurus

Gene ID

Gene Order

ENSMUSG00000055368

View Gene Order

ENSBTAG00000003353

Not yet available

Pathways

NETPATH

REACTOME

REACT_20506

Na+/Cl- dependent neurotransmitter transporters pathway

REACT_19305

Transport of glucose and other sugars, bile salts and organic acids, metal ions and amine compounds pathway

REACT_15518

Transmembrane transport of small molecules pathway

REACT_19118

SLC-mediated transmembrane transport pathway

KEGG

INOH

PID NCI

Cross-References

SwissProt

TrEMBL

UniProt Splice Variant

Entrez Gene

UniGene

Hs.78036

RefSeq

NM_001043 NM_001172501 NM_001172502 NM_001172504 XM_006721263

HUGO

OMIM

CCDS

CCDS10754 CCDS54011 CCDS58463

HPRD

01232

IMGT

EMBL

GenPept

RNA Seq Atlas