InnateDB: Systems Biology of the Innate Immune Response

Homo sapiens Protein: ELMO3

Summary

InnateDB Protein

IDBP-753810.3

Last Modified

2014-10-13 [Report errors or provide feedback]

Gene Symbol

ELMO3

Protein Name

Synonyms

Species

Homo sapiens

Ensembl Protein

ENSP00000458539

InnateDB Gene

IDBG-36322 (ELMO3)

Protein Structure

UniProt Annotation

Function

Involved in cytoskeletal rearrangements required for phagocytosis of apoptotic cells and cell motility. Acts in assocation with DOCK1 and CRK. Was initially proposed to be required in complex with DOCK1 to activate Rac Rho small GTPases. May enhance the guanine nucleotide exchange factor (GEF) activity of DOCK1 (By similarity). {ECO:0000250}.

Subcellular Localization

Cytoplasm {ECO:0000250}.

Disease Associations

Tissue Specificity

Comments

Interactions

Number of Interactions

This gene and/or its encoded proteins are associated with 1 experimentally validated interaction(s) in this database.
They are also associated with 1 interaction(s) predicted by orthology.

Experimentally validated
Total	1 [view]
Protein-Protein	1 [view]
Protein-DNA	0
Protein-RNA	0
DNA-DNA	0
RNA-RNA	0
DNA-RNA	0

Predicted by orthology
Total	1 [view]

Gene Ontology

Molecular Function

Accession	GO Term
GO:0017124	SH3 domain binding

Biological Process

GO:0006909	phagocytosis
GO:0006915	apoptotic process

Cellular Component

GO:0005737	cytoplasm
GO:0005856	cytoskeleton

Protein Structure and Domains

PDB ID

InterPro

IPR006816 Engulfment/cell motility, ELMO
IPR024574 Domain of unknown function DUF3361

PFAM

PF04727
PF11841

PRINTS

PIRSF

SMART

TIGRFAMs

Post-translational Modifications

Modification

Cross-References

SwissProt

Q96BJ8

PhosphoSite

PhosphoSite-Q96BJ8

TrEMBL

UniProt Splice Variant

Entrez Gene

79767

UniGene

Hs.377416

RefSeq

HUGO

HGNC:17289

OMIM

606422

CCDS

HPRD

12104

IMGT

EMBL

AC040160 AK023886 AK300976 BC015524 BC034410

GenPept

AAH15524 AAH34410 BAB14712 BAG62598