InnateDB: Systems Biology of the Innate Immune Response

Homo sapiens Protein: PPP4C

Summary

InnateDB Protein

IDBP-753910.3

Last Modified

2014-10-13 [Report errors or provide feedback]

Gene Symbol

PPP4C

Protein Name

Synonyms

PP4; PP4C; PPH3; PPP4; PPX;

Species

Homo sapiens

Ensembl Protein

ENSP00000455995

InnateDB Gene

IDBG-25572 (PPP4C)

Protein Structure

UniProt Annotation

Function

Protein phosphatase that is involved in many processes such as microtubule organization at centrosomes, maturation of spliceosomal snRNPs, apoptosis, DNA repair, tumor necrosis factor (TNF)-alpha signaling, activation of c-Jun N-terminal kinase MAPK8, regulation of histone acetylation, DNA damage checkpoint signaling, NF-kappa-B activation and cell migration. The PPP4C- PPP4R1 PP4 complex may play a role in dephosphorylation and regulation of HDAC3. The PPP4C-PPP4R2-PPP4R3A PP4 complex specifically dephosphorylates H2AFX phosphorylated on Ser-140 (gamma-H2AFX) generated during DNA replication and required for DNA double strand break repair. Dephosphorylates NDEL1 at CDK1 phosphorylation sites and negatively regulates CDK1 activity in interphase (By similarity). In response to DNA damage, catalyzes RPA2 dephosphorylation, an essential step for DNA repair since it allows the efficient RPA2-mediated recruitment of RAD51 to chromatin. {ECO:0000250, ECO:0000269PubMed:11698396, ECO:0000269PubMed:12668731, ECO:0000269PubMed:12934076, ECO:0000269PubMed:1336397, ECO:0000269PubMed:15805470, ECO:0000269PubMed:18347064, ECO:0000269PubMed:18487071, ECO:0000269PubMed:18614045, ECO:0000269PubMed:18758438, ECO:0000269PubMed:20154705}.

Subcellular Localization

Cytoplasm. Nucleus. Cytoplasm, cytoskeleton, microtubule organizing center, centrosome.

Disease Associations

Tissue Specificity

Comments

Interactions

Number of Interactions

This gene and/or its encoded proteins are associated with 74 experimentally validated interaction(s) in this database.
They are also associated with 1 interaction(s) predicted by orthology.

Experimentally validated
Total	74 [view]
Protein-Protein	73 [view]
Protein-DNA	0
Protein-RNA	1 [view]
DNA-DNA	0
RNA-RNA	0
DNA-RNA	0

Predicted by orthology
Total	1 [view]

Gene Ontology

Molecular Function

Accession	GO Term
GO:0004704	NF-kappaB-inducing kinase activity
GO:0004722	protein serine/threonine phosphatase activity
GO:0005515	protein binding
GO:0016787	hydrolase activity
GO:0046872	metal ion binding

Biological Process

GO:0010569	regulation of double-strand break repair via homologous recombination
GO:0016311	dephosphorylation
GO:0038061	NIK/NF-kappaB signaling
GO:0045087	innate immune response (InnateDB)

Cellular Component

GO:0005634	nucleus
GO:0005737	cytoplasm
GO:0005815	microtubule organizing center
GO:0005886	plasma membrane

Protein Structure and Domains

PDB ID

InterPro

IPR004843 Calcineurin-like phosphoesterase domain, apaH type
IPR006186 Serine/threonine-specific protein phosphatase/bis(5-nucleosyl)-tetraphosphatase
IPR029052 Metallo-dependent phosphatase-like

PFAM

PF00149

PRINTS

PR00114

PIRSF

SMART

SM00156

TIGRFAMs

Post-translational Modifications

Modification

Cross-References

SwissProt