Version 5.4
Homo sapiens Protein: HSBP1
Summary
InnateDB Protein IDBP-754081.3
Last Modified 2014-10-13 [Report errors or provide feedback]
Gene Symbol HSBP1
Protein Name
Synonyms NPC-A-13;
Species Homo sapiens
Ensembl Protein ENSP00000458007
InnateDB Gene IDBG-306658 (HSBP1)
Protein Structure
UniProt Annotation
Function Negative regulator of the heat shock response. Negatively affects HSF1 DNA-binding activity. May have a role in the suppression of the activation of the stress response during the aging process.
Subcellular Localization Nucleus.
Disease Associations
Tissue Specificity
Comments
Interactions
Number of Interactions This gene and/or its encoded proteins are associated with 10 experimentally validated interaction(s) in this database.
They are also associated with 1 interaction(s) predicted by orthology.
Experimentally validated
Total 10 [view]
Protein-Protein 10 [view]
Protein-DNA 0
Protein-RNA 0
DNA-DNA 0
RNA-RNA 0
DNA-RNA 0
Predicted by orthology
Total 1 [view]
Gene Ontology

Molecular Function
Accession GO Term
GO:0003714 transcription corepressor activity
Biological Process
GO:0000122 negative regulation of transcription from RNA polymerase II promoter
Cellular Component
GO:0005634 nucleus
Protein Structure and Domains
PDB ID
InterPro IPR009643 Heat shock factor binding 1
PFAM PF06825
PRINTS
PIRSF
SMART
TIGRFAMs
Post-translational Modifications
Modification
Cross-References
SwissProt O75506
PhosphoSite PhosphoSite-O75506
TrEMBL
UniProt Splice Variant
Entrez Gene 3281
UniGene Hs.741221
RefSeq
HUGO HGNC:5203
OMIM 604553
CCDS CCDS45534
HPRD 05185
IMGT
EMBL AF068754 AY320409 BC007515 BX537440
GenPept AAC25186 AAH07515 AAP73809 CAD97682

If you use InnateDB for your research, please cite the following publication:

Breuer et al., InnateDB: systems biology of innate immunity and beyond - recent updates and continuing curation. Nucl. Acids Res. (2013) 41 (D1) 

InnateDB is being developed jointly by the Brinkman Laboratory (Simon Fraser University, British Columbia, Canada), the Hancock Laboratory (University of British Columbia, Vancouver, British Columbia) and the Lynn EMBL Australia Group (South Australian Health & Medical Research Institute and Flinders University, Adelaide, Australia).

Funding is currently provided by Allergen and EMBL Australia. Previous funding has been provided by Genome Canada, the Foundation for the National Institutes of Health through the Grand Challenges in Global Health initiative and by Teagasc. InnateDB curated interactions are licensed under the Design Science License. All other data is licensed under the terms of the originating database. Contact: innatedb-mail@sfu.ca