Version 5.4
Homo sapiens Protein: SLC5A11
Summary
InnateDB Protein IDBP-754127.3
Last Modified 2014-10-13 [Report errors or provide feedback]
Gene Symbol SLC5A11
Protein Name
Synonyms
Species Homo sapiens
Ensembl Protein ENSP00000454401
InnateDB Gene IDBG-21339 (SLC5A11)
Protein Structure
UniProt Annotation
Function Involved in the sodium-dependent cotransport of myo- inositol (MI) with a Na(+):MI stoichiometry of 2:1. Exclusively responsible for apical MI transport and absorption in intestine. Also can transport D-chiro-inositol (DCI) but not L-fructose. Exhibits stereospecific cotransport of both D-glucose and D- xylose. May induce apoptosis through the TNF-alpha, PDCD1 pathway. May play a role in the regulation of MI concentration in serum, involving reabsorption in at least the proximal tubule of the kidney. {ECO:0000269PubMed:15172003}.
Subcellular Localization Membrane {ECO:0000250UniProtKB:Q28728}; Multi-pass membrane protein {ECO:0000250UniProtKB:Q28728}.
Disease Associations
Tissue Specificity Highest expression in heart, skeletal muscle, kidney, liver and placenta. Weaker expression in brain, colon, spleen, lung and peripheral blood leukocytes. {ECO:0000269PubMed:12039040}.
Comments
Interactions
Number of Interactions This gene and/or its encoded proteins are associated with 0 experimentally validated interaction(s) in this database.
Gene Ontology

Molecular Function
Accession GO Term
GO:0005215 transporter activity
GO:0015293 symporter activity
Biological Process
GO:0006810 transport
GO:0006814 sodium ion transport
GO:0006915 apoptotic process
GO:0008643 carbohydrate transport
GO:0055085 transmembrane transport
Cellular Component
GO:0005886 plasma membrane
GO:0016020 membrane
GO:0016021 integral component of membrane
Protein Structure and Domains
PDB ID
InterPro IPR001734 Sodium/solute symporter
IPR019900 Sodium/solute symporter, subgroup
PFAM PF00474
PRINTS
PIRSF
SMART
TIGRFAMs
Post-translational Modifications
Modification
Cross-References
SwissProt Q8WWX8
PhosphoSite PhosphoSite-Q8WWX8
TrEMBL H3BN85
UniProt Splice Variant
Entrez Gene 115584
UniGene Hs.741965
RefSeq XP_006721078
HUGO HGNC:23091
OMIM 610238
CCDS CCDS58437
HPRD
IMGT
EMBL AC008731 AF292385 AJ305237 AK125267 AK295427 AY044906 BC049385 BC057780 CH471145
GenPept AAH49385 AAH57780 AAK97053 AAK97784 BAC86105 BAH12065 CAC83728 EAW55781

If you use InnateDB for your research, please cite the following publication:

Breuer et al., InnateDB: systems biology of innate immunity and beyond - recent updates and continuing curation. Nucl. Acids Res. (2013) 41 (D1) 

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Funding is currently provided by Allergen and EMBL Australia. Previous funding has been provided by Genome Canada, the Foundation for the National Institutes of Health through the Grand Challenges in Global Health initiative and by Teagasc. InnateDB curated interactions are licensed under the Design Science License. All other data is licensed under the terms of the originating database. Contact: innatedb-mail@sfu.ca