InnateDB: Systems Biology of the Innate Immune Response

Homo sapiens Protein: CHD6

Summary

InnateDB Protein

IDBP-75448.5

Last Modified

2014-10-13 [Report errors or provide feedback]

Gene Symbol

CHD6

Protein Name

chromodomain helicase DNA binding protein 6

Synonyms

Species

Homo sapiens

Ensembl Protein

ENSP00000362330

InnateDB Gene

IDBG-75446 (CHD6)

Protein Structure

UniProt Annotation

Function

Probable chromatin-remodeling protein with a DNA- dependent ATPase activity. May play a role in transcription regulation, activating for instance, the transcription of specific genes in response to oxidative stress through interaction with NFE2L2. {ECO:0000269PubMed:16314513}.

Subcellular Localization

Nucleus, nucleoplasm {ECO:0000269PubMed:17027977}. Note=Enriched at sites of mRNA synthesis.

Disease Associations

Note=A chromosomal aberration disrupting CHD6 has been found in a patient with mild to moderate mental retardation and minor facial anomalies. Translocation t(18;20)(q21.1;q11.2) with TCF4 producing a CHD6-TCF4 fusion transcript (PubMed:18627065). {ECO:0000269PubMed:18627065}.

Tissue Specificity

Widely expressed.

Comments

Interactions

Number of Interactions

This gene and/or its encoded proteins are associated with 10 experimentally validated interaction(s) in this database.

Experimentally validated
Total	10 [view]
Protein-Protein	10 [view]
Protein-DNA	0
Protein-RNA	0
DNA-DNA	0
RNA-RNA	0
DNA-RNA	0

Gene Ontology

Molecular Function

Accession	GO Term
GO:0001221	transcription cofactor binding
GO:0003676	nucleic acid binding
GO:0003677	DNA binding
GO:0003682	chromatin binding
GO:0005515	protein binding
GO:0005524	ATP binding
GO:0008026	ATP-dependent helicase activity
GO:0008094	DNA-dependent ATPase activity
GO:0016787	hydrolase activity
GO:0016817	hydrolase activity, acting on acid anhydrides

Biological Process

GO:0006200	ATP catabolic process
GO:0006351	transcription, DNA-templated
GO:0016568	chromatin modification
GO:0036091	positive regulation of transcription from RNA polymerase II promoter in response to oxidative stress

Cellular Component

GO:0005654	nucleoplasm
GO:0005665	DNA-directed RNA polymerase II, core complex

Protein Structure and Domains

PDB ID

InterPro

IPR000330 SNF2-related
IPR000953 Chromo domain/shadow
IPR001650 Helicase, C-terminal
IPR006576 BRK domain
IPR006935 Helicase/UvrB domain
IPR011545 DEAD/DEAH box helicase domain
IPR014001 Helicase, superfamily 1/2, ATP-binding domain
IPR016197 Chromo domain-like
IPR023780 Chromo domain
IPR027417 P-loop containing nucleoside triphosphate hydrolase

PFAM

PF00176
PF00271
PF07533
PF04851
PF00270
PF00385

PRINTS

PIRSF

SMART

SM00298
SM00490
SM00592
SM00487

TIGRFAMs

Post-translational Modifications

Modification

Cross-References

SwissProt

Q8TD26