Version 5.4
Homo sapiens Gene: CHD6
Summary
InnateDB Gene IDBG-75446.6
Last Modified 2014-10-13 [Report errors or provide feedback]
Gene Symbol CHD6
Gene Name chromodomain helicase DNA binding protein 6
Synonyms
Species Homo sapiens
Ensembl Gene ENSG00000124177
Encoded Proteins
IDBP-75448
chromodomain helicase DNA binding protein 6
IDBP-75450
chromodomain helicase DNA binding protein 6
IDBP-75452
chromodomain helicase DNA binding protein 6
IDBP-375377
chromodomain helicase DNA binding protein 6
IDBP-375384
chromodomain helicase DNA binding protein 6
Protein Structure
Useful resources Stemformatics EHFPI ImmGen
Entrez Gene
Summary Chromosomal DNA of eukaryotic cells is compacted by nuclear proteins to form chromatin, an organized nucleoprotein structure that can inhibit gene expression. Several multisubunit protein complexes exist to remodel the chromatin to allow patterns of cell type-specific gene expression. The protein encoded by this gene is thought to be a core member of one or more of these complexes. The encoded protein, which is a member of the SNF2/RAD54 helicase family, contains two chromodomains, a helicase domain, and an ATPase domain. [provided by RefSeq, Jul 2008]
Gene Information
Type Protein coding
Genomic Location Chromosome 20:41402101-41618494
Strand Reverse strand
Band q12
Transcripts
ENST00000373233 ENSP00000362330
ENST00000309279 ENSP00000308684
ENST00000373222 ENSP00000362319
ENST00000440697 ENSP00000404637
ENST00000440647 ENSP00000392503
ENST00000480022
ENST00000476641
ENST00000470470
ENST00000482596
Interactions
Number of Interactions This gene and/or its encoded proteins are associated with 10 experimentally validated interaction(s) in this database.
Experimentally validated
Total 10 [view]
Protein-Protein 10 [view]
Protein-DNA 0
Protein-RNA 0
DNA-DNA 0
RNA-RNA 0
DNA-RNA 0
Gene Ontology

Molecular Function
Accession GO Term
GO:0001221 transcription cofactor binding
GO:0003676 nucleic acid binding
GO:0003677 DNA binding
GO:0003682 chromatin binding
GO:0005515 protein binding
GO:0005524 ATP binding
GO:0008026 ATP-dependent helicase activity
GO:0008094 DNA-dependent ATPase activity
GO:0016787 hydrolase activity
GO:0016817 hydrolase activity, acting on acid anhydrides
Biological Process
GO:0006200 ATP catabolic process
GO:0006351 transcription, DNA-templated
GO:0016568 chromatin modification
GO:0036091 positive regulation of transcription from RNA polymerase II promoter in response to oxidative stress
Cellular Component
GO:0005654 nucleoplasm
GO:0005665 DNA-directed RNA polymerase II, core complex
Orthologs
Species
Mus musculus
Bos taurus
Gene ID
Gene Order
ENSMUSG00000057133
View Gene Order
ENSBTAG00000005733
Not yet available
Cross-References
SwissProt
TrEMBL
UniProt Splice Variant
Entrez Gene
UniGene Hs.371979 Hs.735095 Hs.740645 Hs.741381
RefSeq NM_032221 XM_005260573 XM_005260575 XM_005260576 XM_006723883
HUGO
OMIM
CCDS CCDS13317
HPRD 13049
IMGT
EMBL
GenPept
RNA Seq Atlas

If you use InnateDB for your research, please cite the following publication:

Breuer et al., InnateDB: systems biology of innate immunity and beyond - recent updates and continuing curation. Nucl. Acids Res. (2013) 41 (D1) 

InnateDB is being developed jointly by the Brinkman Laboratory (Simon Fraser University, British Columbia, Canada), the Hancock Laboratory (University of British Columbia, Vancouver, British Columbia) and the Lynn EMBL Australia Group (South Australian Health & Medical Research Institute and Flinders University, Adelaide, Australia).

Funding is currently provided by Allergen and EMBL Australia. Previous funding has been provided by Genome Canada, the Foundation for the National Institutes of Health through the Grand Challenges in Global Health initiative and by Teagasc. InnateDB curated interactions are licensed under the Design Science License. All other data is licensed under the terms of the originating database. Contact: innatedb-mail@sfu.ca