InnateDB: Systems Biology of the Innate Immune Response

Homo sapiens Protein: EI24

Summary

InnateDB Protein

IDBP-75497.6

Last Modified

2014-10-13 [Report errors or provide feedback]

Gene Symbol

EI24

Protein Name

etoposide induced 2.4 mRNA

Synonyms

EPG4; PIG8; TP53I8;

Species

Homo sapiens

Ensembl Protein

ENSP00000278903

InnateDB Gene

IDBG-75495 (EI24)

Protein Structure

UniProt Annotation

Function

Acts as a negative growth regulator via p53-mediated apoptosis pathway. Regulates formation of degradative autolysosomes during autophagy (By similarity). {ECO:0000250}.

Subcellular Localization

Nucleus membrane {ECO:0000269PubMed:21154811}; Multi-pass membrane protein {ECO:0000269PubMed:21154811}. Cytoplasm {ECO:0000269PubMed:21154811}. Endoplasmic reticulum membrane {ECO:0000250}; Multi-pass membrane protein {ECO:0000250}.

Disease Associations

Note=EI24 is on a chromosomal region frequently deleted in solid tumors, and it is thought to play a role in breast and cervical cancer. Particularly, expression analysis of EI24 in cancerous tissues shows that EI24 loss is associated with tumor invasiveness.

Tissue Specificity

Comments

Interactions

Number of Interactions

This gene and/or its encoded proteins are associated with 1 experimentally validated interaction(s) in this database.

Experimentally validated
Total	1 [view]
Protein-Protein	1 [view]
Protein-DNA	0
Protein-RNA	0
DNA-DNA	0
RNA-RNA	0
DNA-RNA	0

Gene Ontology

Molecular Function

Accession

GO Term

Biological Process

GO:0006914	autophagy
GO:0006915	apoptotic process
GO:0008630	intrinsic apoptotic signaling pathway in response to DNA damage
GO:0030308	negative regulation of cell growth
GO:0042493	response to drug
GO:0050885	neuromuscular process controlling balance
GO:2001244	positive regulation of intrinsic apoptotic signaling pathway