Version 5.4
Homo sapiens Gene: EI24
Summary
InnateDB Gene IDBG-75495.6
Last Modified 2014-10-13 [Report errors or provide feedback]
Gene Symbol EI24
Gene Name etoposide induced 2.4 mRNA
Synonyms EPG4; PIG8; TP53I8
Species Homo sapiens
Ensembl Gene ENSG00000149547
Encoded Proteins
IDBP-75497
etoposide induced 2.4 mRNA
IDBP-599123
etoposide induced 2.4 mRNA
IDBP-808630
etoposide induced 2.4
IDBP-808637
etoposide induced 2.4
IDBP-587339
etoposide induced 2.4 mRNA
IDBP-585688
etoposide induced 2.4 mRNA
IDBP-601672
etoposide induced 2.4 mRNA
IDBP-583740
etoposide induced 2.4 mRNA
IDBP-594392
etoposide induced 2.4 mRNA
IDBP-808629
etoposide induced 2.4
IDBP-808631
etoposide induced 2.4
IDBP-808632
etoposide induced 2.4
Protein Structure
Useful resources Stemformatics EHFPI ImmGen
Entrez Gene
Summary This gene has higher expression in p53-expressing cells than in control cells and is an immediate-early induction target of p53-mediated apoptosis. The protein encoded by this gene contains six putative transmembrane domains and may suppress cell growth by inducing apoptotic cell death through the caspase 9 and mitochondrial pathways. This gene is located on human chromosome 11q24, a region frequently altered in cancers. Alternative splicing results in two transcript variants encoding different isoforms. [provided by RefSeq, Jul 2008]
This gene encodes a putative tumor suppressor and has higher expression in p53-expressing cells than in control cells and is an immediate-early induction target of p53-mediated apoptosis. The encoded protein may suppress cell growth by inducing apoptotic cell death through the caspase 9 and mitochondrial pathways. This gene is located on human chromosome 11q24, a region frequently altered in cancers. Alternative splicing results in multiple transcript variants. Pseudogenes of this gene have been defined on chromosomes 1, 3, 7, and 8. [provided by RefSeq, Feb 2014]
Gene Information
Type Protein coding
Genomic Location Chromosome 11:125569216-125584687
Strand Forward strand
Band q24.2
Transcripts
ENST00000278903 ENSP00000278903
ENST00000529812 ENSP00000436130
ENST00000534546 ENSP00000479943
ENST00000531636 ENSP00000479171
ENST00000524723 ENSP00000435923
ENST00000529765
ENST00000527842 ENSP00000435034
ENST00000527520 ENSP00000435225
ENST00000527131 ENSP00000433376
ENST00000527235 ENSP00000431633
ENST00000530540
ENST00000615917 ENSP00000477849
ENST00000618552 ENSP00000480094
ENST00000620753 ENSP00000484510
Interactions
Number of Interactions This gene and/or its encoded proteins are associated with 1 experimentally validated interaction(s) in this database.
Experimentally validated
Total 1 [view]
Protein-Protein 1 [view]
Protein-DNA 0
Protein-RNA 0
DNA-DNA 0
RNA-RNA 0
DNA-RNA 0
Gene Ontology

Molecular Function
Accession GO Term
Biological Process
GO:0006914 autophagy
GO:0006915 apoptotic process
GO:0008630 intrinsic apoptotic signaling pathway in response to DNA damage
GO:0030308 negative regulation of cell growth
GO:0042493 response to drug
GO:0050885 neuromuscular process controlling balance
GO:2001244 positive regulation of intrinsic apoptotic signaling pathway
Cellular Component
GO:0005789 endoplasmic reticulum membrane
GO:0016020 membrane
GO:0016021 integral component of membrane
GO:0031965 nuclear membrane
Orthologs
Species
Mus musculus
Bos taurus
Gene ID
Gene Order
ENSMUSG00000062762
View Gene Order
ENSBTAG00000007202
Not yet available
Pathways
NETPATH
REACTOME
KEGG
hsa04115
p53 signaling pathway pathway
INOH
PID NCI
Cross-References
SwissProt
TrEMBL E9PLB8
UniProt Splice Variant
Entrez Gene 9538
UniGene Hs.743259
RefSeq NM_001007277 NM_004879
HUGO HGNC:13276
OMIM 605170
CCDS CCDS73410
HPRD 05526
IMGT
EMBL AP001494
GenPept
RNA Seq Atlas 9538

If you use InnateDB for your research, please cite the following publication:

Breuer et al., InnateDB: systems biology of innate immunity and beyond - recent updates and continuing curation. Nucl. Acids Res. (2013) 41 (D1) 

InnateDB is being developed jointly by the Brinkman Laboratory (Simon Fraser University, British Columbia, Canada), the Hancock Laboratory (University of British Columbia, Vancouver, British Columbia) and the Lynn EMBL Australia Group (South Australian Health & Medical Research Institute and Flinders University, Adelaide, Australia).

Funding is currently provided by Allergen and EMBL Australia. Previous funding has been provided by Genome Canada, the Foundation for the National Institutes of Health through the Grand Challenges in Global Health initiative and by Teagasc. InnateDB curated interactions are licensed under the Design Science License. All other data is licensed under the terms of the originating database. Contact: innatedb-mail@sfu.ca