InnateDB: Systems Biology of the Innate Immune Response

Homo sapiens Protein: ARID5B

Summary

InnateDB Protein

IDBP-75502.5

Last Modified

2014-10-13 [Report errors or provide feedback]

Gene Symbol

ARID5B

Protein Name

AT rich interactive domain 5B (MRF1-like)

Synonyms

Species

Homo sapiens

Ensembl Protein

ENSP00000279873

InnateDB Gene

IDBG-75500 (ARID5B)

Protein Structure

UniProt Annotation

Function

Transcription coactivator that binds to the 5'-AATA[CT]- 3' core sequence and plays a key role in adipogenesis and liver development. Acts by forming a complex with phosphorylated PHF2, which mediates demethylation at Lys-336, leading to target the PHF2-ARID5B complex to target promoters, where PHF2 mediates demethylation of dimethylated 'Lys-9' of histone H3 (H3K9me2), followed by transcription activation of target genes. The PHF2- ARID5B complex acts as a coactivator of HNF4A in liver. Required for adipogenesis: regulates triglyceride metabolism in adipocytes by regulating expression of adipogenic genes. Overexpression leads to induction of smooth muscle marker genes, suggesting that it may also act as a regulator of smooth muscle cell differentiation and proliferation. Represses the cytomegalovirus enhancer. {ECO:0000269PubMed:21532585}.

Subcellular Localization

Nucleus {ECO:0000255PROSITE- ProRule:PRU00355}.

Disease Associations

Note=Defects in ARID5B may be a cause of susceptibility to coronary atherosclerosis in the Japanese population.Leukemia, acute lymphoblastic (ALL) [MIM:613065]: A subtype of acute leukemia, a cancer of the white blood cells. ALL is a malignant disease of bone marrow and the most common malignancy diagnosed in children. The malignant cells are lymphoid precursor cells (lymphoblasts) that are arrested in an early stage of development. The lymphoblasts replace the normal marrow elements, resulting in a marked decrease in the production of normal blood cells. Consequently, anemia, thrombocytopenia, and neutropenia occur to varying degrees. The lymphoblasts also proliferate in organs other than the marrow, particularly the liver, spleen, and lymphonodes. {ECO:0000269PubMed:19684603, ECO:0000269PubMed:19684604, ECO:0000269PubMed:20042726, ECO:0000269PubMed:20054350, ECO:0000269PubMed:20189245, ECO:0000269PubMed:20460642, ECO:0000269PubMed:21098271}. Note=Disease susceptibility is associated with variations affecting the gene represented in this entry.

Tissue Specificity

Widely expressed, including in liver (at protein level). {ECO:0000269PubMed:21532585}.

Comments

Interactions

Number of Interactions

This gene and/or its encoded proteins are associated with 10 experimentally validated interaction(s) in this database.
They are also associated with 1 interaction(s) predicted by orthology.

Experimentally validated
Total	10 [view]
Protein-Protein	9 [view]
Protein-DNA	0
Protein-RNA	1 [view]
DNA-DNA	0
RNA-RNA	0
DNA-RNA	0

Predicted by orthology
Total	1 [view]

Gene Ontology

Molecular Function

Accession	GO Term
GO:0003677	DNA binding
GO:0003713	transcription coactivator activity
GO:0005515	protein binding
GO:0044212	transcription regulatory region DNA binding

Biological Process

GO:0001822	kidney development
GO:0001889	liver development
GO:0006351	transcription, DNA-templated
GO:0006807	nitrogen compound metabolic process
GO:0008584	male gonad development
GO:0008585	female gonad development
GO:0009791	post-embryonic development
GO:0010761	fibroblast migration
GO:0030325	adrenal gland development
GO:0035264	multicellular organism growth
GO:0045444	fat cell differentiation
GO:0045892	negative regulation of transcription, DNA-templated
GO:0048008	platelet-derived growth factor receptor signaling pathway
GO:0048468	cell development
GO:0048644	muscle organ morphogenesis
GO:0048705	skeletal system morphogenesis
GO:0051091	positive regulation of sequence-specific DNA binding transcription factor activity
GO:0060021	palate development
GO:0060325	face morphogenesis
GO:0060612	adipose tissue development
GO:0060613	fat pad development