InnateDB: Systems Biology of the Innate Immune Response

Homo sapiens Gene: ARID5B

Summary

InnateDB Gene

IDBG-75500.6

Last Modified

2014-10-13 [Report errors or provide feedback]

Gene Symbol

ARID5B

Gene Name

AT rich interactive domain 5B (MRF1-like)

Synonyms

Species

Homo sapiens

Ensembl Gene

ENSG00000150347

Encoded Proteins

IDBP-75502

AT rich interactive domain 5B (MRF1-like)

IDBP-75504

AT rich interactive domain 5B (MRF1-like)

Protein Structure

Useful resources

Stemformatics EHFPI ImmGen

Entrez Gene

Summary

This gene encodes a member of the AT-rich interaction domain (ARID) family of DNA binding proteins. The encoded protein forms a histone H3K9Me2 demethylase complex with PHD finger protein 2 and regulates the transcription of target genes involved in adipogenesis and liver development. This gene also plays a role in cell growth and differentiation of B-lymphocyte progenitors, and single nucleotide polymorphisms in this gene are associated with acute lymphoblastic leukemia. Alternatively spliced transcript variants encoding multiple isoforms have been observed for this gene. [provided by RefSeq, Sep 2011]

Gene Information

Type

Protein coding

Genomic Location

Chromosome 10:61901300-62096944

Strand

Forward strand

Band

q21.2

Transcripts

ENST00000279873	ENSP00000279873
ENST00000309334	ENSP00000308862

Interactions

Number of Interactions

This gene and/or its encoded proteins are associated with 10 experimentally validated interaction(s) in this database.
They are also associated with 1 interaction(s) predicted by orthology.

Experimentally validated
Total	10 [view]
Protein-Protein	9 [view]
Protein-DNA	0
Protein-RNA	1 [view]
DNA-DNA	0
RNA-RNA	0
DNA-RNA	0

Predicted by orthology
Total	1 [view]

Gene Ontology

Molecular Function

Accession	GO Term
GO:0003677	DNA binding
GO:0003713	transcription coactivator activity
GO:0005515	protein binding
GO:0044212	transcription regulatory region DNA binding

Biological Process

GO:0001822	kidney development
GO:0001889	liver development
GO:0006351	transcription, DNA-templated
GO:0006807	nitrogen compound metabolic process
GO:0008584	male gonad development
GO:0008585	female gonad development
GO:0009791	post-embryonic development
GO:0010761	fibroblast migration
GO:0030325	adrenal gland development
GO:0035264	multicellular organism growth
GO:0045444	fat cell differentiation
GO:0045892	negative regulation of transcription, DNA-templated
GO:0048008	platelet-derived growth factor receptor signaling pathway
GO:0048468	cell development
GO:0048644	muscle organ morphogenesis
GO:0048705	skeletal system morphogenesis
GO:0051091	positive regulation of sequence-specific DNA binding transcription factor activity
GO:0060021	palate development
GO:0060325	face morphogenesis
GO:0060612	adipose tissue development
GO:0060613	fat pad development

Cellular Component

GO:0005622	intracellular
GO:0005634	nucleus

Orthologs

Species

Mus musculus

Bos taurus

Gene ID

Gene Order

ENSMUSG00000019947

View Gene Order

ENSBTAG00000006729

Not yet available

Pathways

NETPATH

REACTOME

REACT_228178

HDMs demethylate histones pathway

REACT_172623

Chromatin organization pathway

REACT_172633

Chromatin modifying enzymes pathway

KEGG

INOH

PID NCI

Cross-References

SwissProt

Q14865

TrEMBL

UniProt Splice Variant

Entrez Gene

84159

UniGene

Hs.535297 Hs.603419 Hs.643774

RefSeq

NM_001244638 NM_032199

HUGO

HGNC:17362

OMIM

608538

CCDS

CCDS58082 CCDS31208

HPRD

IMGT

EMBL

AC067742 AK024803 AK296921 AL671972 BC015120 BC036831 BC066345 BC107800 BX537690 BX641020 M73837

GenPept

AAA59870 AAH15120 AAH36831 AAH66345 AAI07801 BAB15012 BAG59475 CAD97814 CAE46013 CAH72685 CAH72686

RNA Seq Atlas

84159