InnateDB Protein
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IDBP-75504.6
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Last Modified
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2014-10-13 [Report errors or provide feedback]
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Gene Symbol
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ARID5B
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Protein Name
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AT rich interactive domain 5B (MRF1-like)
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Synonyms
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Species
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Homo sapiens
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Ensembl Protein
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ENSP00000308862
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InnateDB Gene
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IDBG-75500 (ARID5B)
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Protein Structure
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Function |
Transcription coactivator that binds to the 5'-AATA[CT]- 3' core sequence and plays a key role in adipogenesis and liver development. Acts by forming a complex with phosphorylated PHF2, which mediates demethylation at Lys-336, leading to target the PHF2-ARID5B complex to target promoters, where PHF2 mediates demethylation of dimethylated 'Lys-9' of histone H3 (H3K9me2), followed by transcription activation of target genes. The PHF2- ARID5B complex acts as a coactivator of HNF4A in liver. Required for adipogenesis: regulates triglyceride metabolism in adipocytes by regulating expression of adipogenic genes. Overexpression leads to induction of smooth muscle marker genes, suggesting that it may also act as a regulator of smooth muscle cell differentiation and proliferation. Represses the cytomegalovirus enhancer. {ECO:0000269PubMed:21532585}.
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Subcellular Localization |
Nucleus {ECO:0000255PROSITE- ProRule:PRU00355}.
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Disease Associations |
Note=Defects in ARID5B may be a cause of susceptibility to coronary atherosclerosis in the Japanese population.Leukemia, acute lymphoblastic (ALL) [MIM:613065]: A subtype of acute leukemia, a cancer of the white blood cells. ALL is a malignant disease of bone marrow and the most common malignancy diagnosed in children. The malignant cells are lymphoid precursor cells (lymphoblasts) that are arrested in an early stage of development. The lymphoblasts replace the normal marrow elements, resulting in a marked decrease in the production of normal blood cells. Consequently, anemia, thrombocytopenia, and neutropenia occur to varying degrees. The lymphoblasts also proliferate in organs other than the marrow, particularly the liver, spleen, and lymphonodes. {ECO:0000269PubMed:19684603, ECO:0000269PubMed:19684604, ECO:0000269PubMed:20042726, ECO:0000269PubMed:20054350, ECO:0000269PubMed:20189245, ECO:0000269PubMed:20460642, ECO:0000269PubMed:21098271}. Note=Disease susceptibility is associated with variations affecting the gene represented in this entry.
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Tissue Specificity |
Widely expressed, including in liver (at protein level). {ECO:0000269PubMed:21532585}.
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Comments |
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Number of Interactions
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This gene and/or its encoded proteins are associated with 10 experimentally validated interaction(s) in this database.
They are also associated with 1 interaction(s) predicted by orthology.
Experimentally validated |
Total |
10
[view]
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Protein-Protein |
9
[view]
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Protein-DNA |
0
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Protein-RNA |
1
[view]
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DNA-DNA |
0
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RNA-RNA |
0
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DNA-RNA |
0
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Predicted by orthology |
Total |
1 [view]
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Molecular Function |
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Biological Process |
GO:0001889
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liver development
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GO:0006351
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transcription, DNA-templated
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GO:0045892
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negative regulation of transcription, DNA-templated
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GO:0051091
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positive regulation of sequence-specific DNA binding transcription factor activity
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GO:0060612
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adipose tissue development
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Cellular Component |
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PDB ID |
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InterPro |
IPR001606
ARID/BRIGHT DNA-binding domain
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PFAM |
PF01388
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PRINTS |
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PIRSF |
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SMART |
SM00501
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TIGRFAMs |
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Modification |
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SwissProt |
Q14865
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PhosphoSite |
PhosphoSite-Q14865
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TrEMBL |
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UniProt Splice Variant |
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Entrez Gene |
84159
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UniGene |
Hs.643774
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RefSeq |
NP_001231567
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HUGO |
HGNC:17362
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OMIM |
608538
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CCDS |
CCDS58082
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HPRD |
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IMGT |
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EMBL |
AC067742
AK024803
AK296921
AL671972
BC015120
BC036831
BC066345
BC107800
BX537690
BX641020
M73837
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GenPept |
AAA59870
AAH15120
AAH36831
AAH66345
AAI07801
BAB15012
BAG59475
CAD97814
CAE46013
CAH72685
CAH72686
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