InnateDB: Systems Biology of the Innate Immune Response

Homo sapiens Protein: CHN1

Summary

InnateDB Protein

IDBP-75595.7

Last Modified

2014-10-13 [Report errors or provide feedback]

Gene Symbol

CHN1

Protein Name

chimerin (chimaerin) 1

Synonyms

ARHGAP2; CHN; DURS2; NC; RHOGAP2;

Species

Homo sapiens

Ensembl Protein

ENSP00000295497

InnateDB Gene

IDBG-75593 (CHN1)

Protein Structure

UniProt Annotation

Function

GTPase-activating protein for p21-rac and a phorbol ester receptor. Involved in the assembly of neuronal locomotor circuits as a direct effector of EPHA4 in axon guidance.

Subcellular Localization

Disease Associations

Duane retraction syndrome 2 (DURS2) [MIM:604356]: Duane retraction syndrome is a congenital eye movement disorder characterized by a failure of cranial nerve VI (the abducens nerve) to develop normally, resulting in restriction or absence of abduction, adduction, or both, and narrowing of the palpebral fissure and retraction of the globe on attempted adduction. Undiagnosed in children, it can lead to amblyopia, a permanent uncorrectable loss of vision. {ECO:0000269PubMed:18653847}. Note=The disease is caused by mutations affecting the gene represented in this entry.

Tissue Specificity

In neurons in brain regions that are involved in learning and memory processes.

Comments

Interactions

Number of Interactions

This gene and/or its encoded proteins are associated with 14 experimentally validated interaction(s) in this database.
They are also associated with 1 interaction(s) predicted by orthology.

Experimentally validated
Total	14 [view]
Protein-Protein	14 [view]
Protein-DNA	0
Protein-RNA	0
DNA-DNA	0
RNA-RNA	0
DNA-RNA	0

Predicted by orthology
Total	1 [view]

Gene Ontology

Molecular Function

Accession	GO Term
GO:0005070	SH3/SH2 adaptor activity
GO:0005096	GTPase activator activity
GO:0046872	metal ion binding

Biological Process

GO:0007165	signal transduction
GO:0007264	small GTPase mediated signal transduction
GO:0008045	motor neuron axon guidance
GO:0009967	positive regulation of signal transduction
GO:0035556	intracellular signal transduction
GO:0043547	positive regulation of GTPase activity
GO:0048013	ephrin receptor signaling pathway
GO:0050770	regulation of axonogenesis
GO:0051056	regulation of small GTPase mediated signal transduction

Cellular Component

GO:0005622	intracellular
GO:0005829	cytosol

Protein Structure and Domains

PDB ID

InterPro

IPR000198 Rho GTPase-activating protein domain
IPR002219 Protein kinase C-like, phorbol ester/diacylglycerol-binding domain
IPR008936 Rho GTPase activation protein
IPR020454 Diacylglycerol/phorbol-ester binding

PFAM

PF00620
PF00130

PRINTS

PR00008

PIRSF

SMART

SM00324
SM00109

TIGRFAMs

Post-translational Modifications

Modification

Cross-References

SwissProt