InnateDB: Systems Biology of the Innate Immune Response

Homo sapiens Protein: TRIM31

Summary

InnateDB Protein

IDBP-75696.6

Last Modified

2014-10-13 [Report errors or provide feedback]

Gene Symbol

TRIM31

Protein Name

tripartite motif containing 31

Synonyms

C6orf13; HCG1; HCGI; RNF;

Species

Homo sapiens

Ensembl Protein

ENSP00000365924

InnateDB Gene

IDBG-75694 (TRIM31)

Protein Structure

UniProt Annotation

Function

Regulator of Src-induced anchorage independent cell growth (By similarity). May have E3 ubiquitin-protein ligase activity. {ECO:0000250, ECO:0000269PubMed:18773414}.

Subcellular Localization

Cytoplasm {ECO:0000269PubMed:18773414}. Mitochondrion {ECO:0000269PubMed:18773414}. Note=Predominantly expressed in the cytoplasm but a fraction is associated with the mitochondria.

Disease Associations

Tissue Specificity

Up-regulated in gastric adenocarcinomas. {ECO:0000269PubMed:18773414}.

Comments

Interactions

Number of Interactions

This gene and/or its encoded proteins are associated with 17 experimentally validated interaction(s) in this database.
They are also associated with 1 interaction(s) predicted by orthology.

Experimentally validated
Total	17 [view]
Protein-Protein	17 [view]
Protein-DNA	0
Protein-RNA	0
DNA-DNA	0
RNA-RNA	0
DNA-RNA	0

Predicted by orthology
Total	1 [view]

Gene Ontology

Molecular Function

Accession	GO Term
GO:0005515	protein binding
GO:0008270	zinc ion binding
GO:0016874	ligase activity
GO:0046872	metal ion binding

Biological Process

GO:0016567	protein ubiquitination
GO:0032897	negative regulation of viral transcription
GO:0045087	innate immune response
GO:0046597	negative regulation of viral entry into host cell
GO:0051091	positive regulation of sequence-specific DNA binding transcription factor activity
GO:1902186	regulation of viral release from host cell