Version 5.4
Homo sapiens Protein: DDX25
Summary
InnateDB Protein IDBP-75703.6
Last Modified 2014-10-13 [Report errors or provide feedback]
Gene Symbol DDX25
Protein Name DEAD (Asp-Glu-Ala-Asp) box polypeptide 25
Synonyms
Species Homo sapiens
Ensembl Protein ENSP00000263576
InnateDB Gene IDBG-75701 (DDX25)
Protein Structure
UniProt Annotation
Function ATP-dependent RNA helicase. Required for mRNA export and translation regulation during spermatid development (By similarity). {ECO:0000250}.
Subcellular Localization Cytoplasm {ECO:0000269PubMed:10608860}. Nucleus {ECO:0000250}. Note=Detected in both cytoplasm and nucleus of testicular cells. Also detected in chromatoid bodies of round spermatids (By similarity). {ECO:0000250}.
Disease Associations
Tissue Specificity Highly expressed in the Leydig and germ cells of the testis and weakly expressed in the pituitary and hypothalamus. {ECO:0000269PubMed:10608860, ECO:0000269Ref.2}.
Comments
Interactions
Number of Interactions This gene and/or its encoded proteins are associated with 1 experimentally validated interaction(s) in this database.
Experimentally validated
Total 1 [view]
Protein-Protein 0
Protein-DNA 1 [view]
Protein-RNA 0
DNA-DNA 0
RNA-RNA 0
DNA-RNA 0
Gene Ontology

Molecular Function
Accession GO Term
GO:0003676 nucleic acid binding
GO:0003723 RNA binding
GO:0004004 ATP-dependent RNA helicase activity
GO:0005524 ATP binding
Biological Process
GO:0006200 ATP catabolic process
GO:0006406 mRNA export from nucleus
GO:0006417 regulation of translation
GO:0007275 multicellular organismal development
GO:0007286 spermatid development
Cellular Component
GO:0005634 nucleus
GO:0005737 cytoplasm
GO:0033391 chromatoid body
Protein Structure and Domains
PDB ID
InterPro IPR001650 Helicase, C-terminal
IPR011545 DEAD/DEAH box helicase domain
IPR014001 Helicase, superfamily 1/2, ATP-binding domain
IPR014014 RNA helicase, DEAD-box type, Q motif
IPR027417 P-loop containing nucleoside triphosphate hydrolase
PFAM PF00271
PF00270
PRINTS
PIRSF
SMART SM00490
SM00487
TIGRFAMs
Post-translational Modifications
Modification
Cross-References
SwissProt Q9UHL0
PhosphoSite PhosphoSite-Q9UHL0
TrEMBL B4YF11
UniProt Splice Variant
Entrez Gene 29118
UniGene Hs.420263
RefSeq NP_037396
HUGO HGNC:18698
OMIM 607663
CCDS CCDS44766
HPRD 06367
IMGT
EMBL AF155140 AK312772 AY735301 AY735302 AY735303 AY735304 AY735305 AY735306 AY735307 AY735308 AY735309 AY735310 AY735311 AY735312 BC035388 BC050360 CH471065 EU076465 EU519226
GenPept AAF21371 AAH35388 AAH50360 AAU84667 ABW87007 ACA64098 BAG35637 EAW67669

If you use InnateDB for your research, please cite the following publication:

Breuer et al., InnateDB: systems biology of innate immunity and beyond - recent updates and continuing curation. Nucl. Acids Res. (2013) 41 (D1) 

InnateDB is being developed jointly by the Brinkman Laboratory (Simon Fraser University, British Columbia, Canada), the Hancock Laboratory (University of British Columbia, Vancouver, British Columbia) and the Lynn EMBL Australia Group (South Australian Health & Medical Research Institute and Flinders University, Adelaide, Australia).

Funding is currently provided by Allergen and EMBL Australia. Previous funding has been provided by Genome Canada, the Foundation for the National Institutes of Health through the Grand Challenges in Global Health initiative and by Teagasc. InnateDB curated interactions are licensed under the Design Science License. All other data is licensed under the terms of the originating database. Contact: innatedb-mail@sfu.ca