Version 5.4
Homo sapiens Gene: DDX25
Summary
InnateDB Gene IDBG-75701.7
Last Modified 2014-10-13 [Report errors or provide feedback]
Gene Symbol DDX25
Gene Name DEAD (Asp-Glu-Ala-Asp) box helicase 25
Synonyms
Species Homo sapiens
Ensembl Gene ENSG00000109832
Encoded Proteins
IDBP-75703
DEAD (Asp-Glu-Ala-Asp) box polypeptide 25
IDBP-718452
IDBP-602935
DEAD (Asp-Glu-Ala-Asp) box polypeptide 25
IDBP-603604
DEAD (Asp-Glu-Ala-Asp) box polypeptide 25
IDBP-718855
Protein Structure
Useful resources Stemformatics EHFPI ImmGen
Entrez Gene
Summary DEAD box proteins, characterized by the conserved motif Asp-Glu-Ala-Asp (DEAD), are putative RNA helicases. They are implicated in a number of cellular processes involving alteration of RNA secondary structure, such as translation initiation, nuclear and mitochondrial splicing, and ribosome and spliceosome assembly. Based on their distribution patterns, some members of the DEAD box protein family are believed to be involved in embryogenesis, spermatogenesis, and cellular growth and division. This gene encodes a member of this family. The encoded protein is a gonadotropin-regulated and developmentally expressed testicular RNA helicase. It may serve to maintain testicular functions related to steroidogenesis and spermatogenesis. [provided by RefSeq, Jul 2008]
Gene Information
Type Protein coding
Genomic Location Chromosome 11:125903376-125923263
Strand Forward strand
Band q24.2
Transcripts
ENST00000263576 ENSP00000263576
ENST00000525943
ENST00000530414 ENSP00000463333
ENST00000530129 ENSP00000432800
ENST00000526875 ENSP00000436087
ENST00000531000
ENST00000532928
ENST00000584970 ENSP00000464251
Interactions
Number of Interactions This gene and/or its encoded proteins are associated with 1 experimentally validated interaction(s) in this database.
Experimentally validated
Total 1 [view]
Protein-Protein 0
Protein-DNA 1 [view]
Protein-RNA 0
DNA-DNA 0
RNA-RNA 0
DNA-RNA 0
Gene Ontology

Molecular Function
Accession GO Term
GO:0003676 nucleic acid binding
GO:0003723 RNA binding
GO:0004004 ATP-dependent RNA helicase activity
GO:0004386 helicase activity
GO:0005524 ATP binding
Biological Process
GO:0006200 ATP catabolic process
GO:0006406 mRNA export from nucleus
GO:0006417 regulation of translation
GO:0007275 multicellular organismal development
GO:0007286 spermatid development
GO:0008152 metabolic process
Cellular Component
GO:0005634 nucleus
GO:0005737 cytoplasm
GO:0033391 chromatoid body
Orthologs
Species
Mus musculus
Bos taurus
Gene ID
Gene Order
ENSMUSG00000032101
View Gene Order
ENSBTAG00000004266
Not yet available
Cross-References
SwissProt
TrEMBL
UniProt Splice Variant
Entrez Gene
UniGene Hs.420263
RefSeq NM_013264
HUGO
OMIM
CCDS CCDS44766
HPRD 06367
IMGT
EMBL
GenPept
RNA Seq Atlas

If you use InnateDB for your research, please cite the following publication:

Breuer et al., InnateDB: systems biology of innate immunity and beyond - recent updates and continuing curation. Nucl. Acids Res. (2013) 41 (D1) 

InnateDB is being developed jointly by the Brinkman Laboratory (Simon Fraser University, British Columbia, Canada), the Hancock Laboratory (University of British Columbia, Vancouver, British Columbia) and the Lynn EMBL Australia Group (South Australian Health & Medical Research Institute and Flinders University, Adelaide, Australia).

Funding is currently provided by Allergen and EMBL Australia. Previous funding has been provided by Genome Canada, the Foundation for the National Institutes of Health through the Grand Challenges in Global Health initiative and by Teagasc. InnateDB curated interactions are licensed under the Design Science License. All other data is licensed under the terms of the originating database. Contact: innatedb-mail@sfu.ca