Version 5.4
Homo sapiens Protein: CDON
Summary
InnateDB Protein IDBP-75709.7
Last Modified 2014-10-13 [Report errors or provide feedback]
Gene Symbol CDON
Protein Name Cdon homolog (mouse)
Synonyms
Species Homo sapiens
Ensembl Protein ENSP00000263577
InnateDB Gene IDBG-75707 (CDON)
Protein Structure
UniProt Annotation
Function Component of a cell-surface receptor complex that mediates cell-cell interactions between muscle precursor cells. Promotes differentiation of myogenic cells (By similarity). {ECO:0000250}.
Subcellular Localization Cell membrane {ECO:0000250}; Single-pass membrane protein {ECO:0000250}.
Disease Associations Holoprosencephaly 11 (HPE11) [MIM:614226]: A structural anomaly of the brain, in which the developing forebrain fails to correctly separate into right and left hemispheres. Holoprosencephaly is genetically heterogeneous and associated with several distinct facies and phenotypic variability. {ECO:0000269PubMed:21802063}. Note=The disease is caused by mutations affecting the gene represented in this entry.
Tissue Specificity
Comments
Interactions
Number of Interactions This gene and/or its encoded proteins are associated with 7 experimentally validated interaction(s) in this database.
They are also associated with 4 interaction(s) predicted by orthology.
Experimentally validated
Total 7 [view]
Protein-Protein 7 [view]
Protein-DNA 0
Protein-RNA 0
DNA-DNA 0
RNA-RNA 0
DNA-RNA 0
Predicted by orthology
Total 4 [view]
Gene Ontology

Molecular Function
Accession GO Term
GO:0005515 protein binding
Biological Process
GO:0007155 cell adhesion
GO:0042692 muscle cell differentiation
GO:0051149 positive regulation of muscle cell differentiation
Cellular Component
GO:0005886 plasma membrane
GO:0016021 integral component of membrane
GO:0031012 extracellular matrix
Protein Structure and Domains
PDB ID
InterPro IPR003598 Immunoglobulin subtype 2
IPR003599 Immunoglobulin subtype
IPR003961 Fibronectin, type III
IPR007110 Immunoglobulin-like domain
IPR013098 Immunoglobulin I-set
IPR013151 Immunoglobulin
PFAM PF00041
PF01108
PF07679
PF00047
PRINTS
PIRSF
SMART SM00408
SM00409
SM00060
TIGRFAMs
Post-translational Modifications
Modification
Cross-References
SwissProt Q4KMG0
PhosphoSite PhosphoSite-Q4KMG0
TrEMBL E9PRD8
UniProt Splice Variant
Entrez Gene 50937
UniGene Hs.727698
RefSeq NP_058648
HUGO HGNC:17104
OMIM 608707
CCDS CCDS8468
HPRD 16372
IMGT
EMBL AF004841 AP000821 AP000842 BC098583
GenPept AAC34901 AAH98583

If you use InnateDB for your research, please cite the following publication:

Breuer et al., InnateDB: systems biology of innate immunity and beyond - recent updates and continuing curation. Nucl. Acids Res. (2013) 41 (D1) 

InnateDB is being developed jointly by the Brinkman Laboratory (Simon Fraser University, British Columbia, Canada), the Hancock Laboratory (University of British Columbia, Vancouver, British Columbia) and the Lynn EMBL Australia Group (South Australian Health & Medical Research Institute and Flinders University, Adelaide, Australia).

Funding is currently provided by Allergen and EMBL Australia. Previous funding has been provided by Genome Canada, the Foundation for the National Institutes of Health through the Grand Challenges in Global Health initiative and by Teagasc. InnateDB curated interactions are licensed under the Design Science License. All other data is licensed under the terms of the originating database. Contact: innatedb-mail@sfu.ca