Version 5.4
Homo sapiens Protein: CD300LF
Summary
InnateDB Protein IDBP-758205.3
Last Modified 2014-10-13 [Report errors or provide feedback]
Gene Symbol CD300LF
Protein Name
Synonyms
Species Homo sapiens
Ensembl Protein ENSP00000464223
InnateDB Gene IDBG-67452 (CD300LF)
Protein Structure
UniProt Annotation
Function Acts as an inhibitory receptor for myeloid cells and mast cells. Inhibits osteoclast formation. {ECO:0000269PubMed:15549731}.
Subcellular Localization Cell membrane {ECO:0000305}; Single-pass type I membrane protein {ECO:0000305}.
Disease Associations
Tissue Specificity Highly expressed in spleen, peripheral blood leukocyte and monocyte, and lung. Weakly expressed in thymus, heart, brain, placenta, liver, skeletal muscle, kidney, pancreas, prostate, testis, ovary, small intestine or colon. Expressed selectively in monocytes and monocyte-related cells. {ECO:0000269PubMed:15184070, ECO:0000269PubMed:15549731}.
Comments
Interactions
Number of Interactions This gene and/or its encoded proteins are associated with 2 experimentally validated interaction(s) in this database.
They are also associated with 1 interaction(s) predicted by orthology.
Experimentally validated
Total 2 [view]
Protein-Protein 2 [view]
Protein-DNA 0
Protein-RNA 0
DNA-DNA 0
RNA-RNA 0
DNA-RNA 0
Predicted by orthology
Total 1 [view]
Gene Ontology

Molecular Function
Accession GO Term
GO:0005515 protein binding
Biological Process
GO:0002376 immune system process
GO:0045087 innate immune response (InnateDB)
Cellular Component
GO:0005886 plasma membrane
GO:0016021 integral component of membrane
Protein Structure and Domains
PDB ID
InterPro IPR003599 Immunoglobulin subtype
IPR007110 Immunoglobulin-like domain
IPR013106 Immunoglobulin V-set domain
PFAM PF07686
PRINTS
PIRSF
SMART SM00409
TIGRFAMs
Post-translational Modifications
Modification
Cross-References
SwissProt Q8TDQ1
PhosphoSite PhosphoSite-Q8TDQ1
TrEMBL
UniProt Splice Variant
Entrez Gene 146722
UniGene Hs.567706
RefSeq
HUGO HGNC:29883
OMIM 609807
CCDS
HPRD 17635
IMGT
EMBL AC016888 AC064805 AF251706 AF375480 AF375481 AK092757 AK315165 AY303545 AY358545 BC028199 DQ153249
GenPept AAH28199 AAM19099 AAP42152 AAP42153 AAP57942 AAQ88909 AAZ81566 BAC03966 BAG37609

If you use InnateDB for your research, please cite the following publication:

Breuer et al., InnateDB: systems biology of innate immunity and beyond - recent updates and continuing curation. Nucl. Acids Res. (2013) 41 (D1) 

InnateDB is being developed jointly by the Brinkman Laboratory (Simon Fraser University, British Columbia, Canada), the Hancock Laboratory (University of British Columbia, Vancouver, British Columbia) and the Lynn EMBL Australia Group (South Australian Health & Medical Research Institute and Flinders University, Adelaide, Australia).

Funding is currently provided by Allergen and EMBL Australia. Previous funding has been provided by Genome Canada, the Foundation for the National Institutes of Health through the Grand Challenges in Global Health initiative and by Teagasc. InnateDB curated interactions are licensed under the Design Science License. All other data is licensed under the terms of the originating database. Contact: innatedb-mail@sfu.ca