InnateDB: Systems Biology of the Innate Immune Response

Homo sapiens Protein: NME4

Summary

InnateDB Protein

IDBP-7583.6

Last Modified

2014-10-13 [Report errors or provide feedback]

Gene Symbol

NME4

Protein Name

non-metastatic cells 4, protein expressed in

Synonyms

NDPK-D; nm23-H4; NM23H4;

Species

Homo sapiens

Ensembl Protein

ENSP00000219479

InnateDB Gene

IDBG-7601 (NME4)

Protein Structure

UniProt Annotation

Function

Major role in the synthesis of nucleoside triphosphates other than ATP. {ECO:0000250}.

Subcellular Localization

Mitochondrion intermembrane space.

Disease Associations

Tissue Specificity

Widely distributed. Found at very high levels in prostate, heart, liver, small intestine, and skeletal muscle tissues, and in low amounts in the brain and in blood leukocytes.

Comments

Interactions

Number of Interactions

This gene and/or its encoded proteins are associated with 19 experimentally validated interaction(s) in this database.

Experimentally validated
Total	19 [view]
Protein-Protein	19 [view]
Protein-DNA	0
Protein-RNA	0
DNA-DNA	0
RNA-RNA	0
DNA-RNA	0

Gene Ontology

Molecular Function

Accession	GO Term
GO:0004550	nucleoside diphosphate kinase activity
GO:0005515	protein binding
GO:0005524	ATP binding
GO:0032403	protein complex binding
GO:0046872	metal ion binding

Biological Process

GO:0006165	nucleoside diphosphate phosphorylation
GO:0006183	GTP biosynthetic process
GO:0006228	UTP biosynthetic process
GO:0006241	CTP biosynthetic process
GO:0009116	nucleoside metabolic process
GO:0015949	nucleobase-containing small molecule interconversion
GO:0044281	small molecule metabolic process
GO:0055086	nucleobase-containing small molecule metabolic process