Homo sapiens Gene: NME4
Summary
InnateDB Gene IDBG-7601.7
Last Modified 2014-10-13 [Report errors or provide feedback]
Gene Symbol NME4
Gene Name NME/NM23 nucleoside diphosphate kinase 4
Synonyms NDPK-D; nm23-H4; NM23H4
Species Homo sapiens
Ensembl Gene ENSG00000103202
Encoded Proteins
non-metastatic cells 4, protein expressed in
non-metastatic cells 4, protein expressed in
non-metastatic cells 4, protein expressed in
non-metastatic cells 4, protein expressed in
non-metastatic cells 4, protein expressed in
non-metastatic cells 4, protein expressed in
non-metastatic cells 4, protein expressed in
non-metastatic cells 4, protein expressed in
NME/NM23 nucleoside diphosphate kinase 4
NME/NM23 nucleoside diphosphate kinase 4
Protein Structure
Useful resources Stemformatics EHFPI ImmGen
Entrez Gene
Summary The nucleoside diphosphate (NDP) kinases (EC 2.7.4.6) are ubiquitous enzymes that catalyze transfer of gamma-phosphates, via a phosphohistidine intermediate, between nucleoside and dioxynucleoside tri- and diphosphates. The enzymes are products of the nm23 gene family, which includes NME4 (Milon et al., 1997 [PubMed 9099850]).[supplied by OMIM, May 2008]
Gene Information
Type Protein coding
Genomic Location Chromosome 16:396725-410367
Strand Forward strand
Band p13.3
Transcripts
ENST00000382940 ENSP00000372398
ENST00000219479 ENSP00000219479
ENST00000397722 ENSP00000380834
ENST00000454619 ENSP00000406317
ENST00000448828 ENSP00000412039
ENST00000444498 ENSP00000395605
ENST00000433358 ENSP00000405925
ENST00000450036 ENSP00000389048
ENST00000460297
ENST00000468031
ENST00000620944 ENSP00000479996
ENST00000621774 ENSP00000479681
Interactions
Number of Interactions This gene and/or its encoded proteins are associated with 19 experimentally validated interaction(s) in this database.
Experimentally validated
Total 19 [view]
Protein-Protein 19 [view]
Protein-DNA 0
Protein-RNA 0
DNA-DNA 0
RNA-RNA 0
DNA-RNA 0
Gene Ontology

Molecular Function
Accession GO Term
GO:0004550 nucleoside diphosphate kinase activity
GO:0005515 protein binding
GO:0005524 ATP binding
GO:0032403 protein complex binding
GO:0046872 metal ion binding
Biological Process
GO:0006165 nucleoside diphosphate phosphorylation
GO:0006183 GTP biosynthetic process
GO:0006228 UTP biosynthetic process
GO:0006241 CTP biosynthetic process
GO:0009116 nucleoside metabolic process
GO:0015949 nucleobase-containing small molecule interconversion
GO:0044281 small molecule metabolic process
GO:0055086 nucleobase-containing small molecule metabolic process
Cellular Component
GO:0005739 mitochondrion
GO:0005743 mitochondrial inner membrane
GO:0005758 mitochondrial intermembrane space
Orthologs
Species
Mus musculus
Bos taurus
Gene ID
Gene Order
Not yet available
Pathways
NETPATH
REACTOME
Synthesis and interconversion of nucleotide di- and triphosphates pathway
Metabolism of nucleotides pathway
Metabolism pathway
KEGG
Pyrimidine metabolism pathway
Purine metabolism pathway
INOH
Folate metabolism pathway
Purine nucleotides nucleosides metabolism pathway
Pyrimidine nucleotides nucleosides metabolism pathway
PID NCI
Cross-References
SwissProt
TrEMBL A2IDC9
UniProt Splice Variant
Entrez Gene 4833
UniGene
RefSeq NM_001286438 NM_001286439 NM_001286433 NM_001286435 NM_001286436 NM_001286440 NM_005009
HUGO HGNC:7852
OMIM 601818
CCDS CCDS66886 CCDS10408 CCDS73797
HPRD
IMGT
EMBL AL023881 Z97634
GenPept
RNA Seq Atlas 4833