InnateDB: Systems Biology of the Innate Immune Response

Homo sapiens Protein: ST3GAL4

Summary

InnateDB Protein

IDBP-75844.7

Last Modified

2014-10-13 [Report errors or provide feedback]

Gene Symbol

ST3GAL4

Protein Name

ST3 beta-galactoside alpha-2,3-sialyltransferase 4

Synonyms

CGS23; NANTA3; SAT3; SIAT4; SIAT4C; ST3GalIV; STZ;

Species

Homo sapiens

Ensembl Protein

ENSP00000348451

InnateDB Gene

IDBG-75840 (ST3GAL4)

Protein Structure

UniProt Annotation

Function

It may catalyze the formation of the NeuAc-alpha-2,3- Gal-beta-1,3-GalNAc- or NeuAc-alpha-2,3-Gal-beta-1,3-GlcNAc- sequences found in terminal carbohydrate groups of glycoproteins and glycolipids. It may be involved in the biosynthesis of the sialyl Lewis X determinant. Also acts on the corresponding 1,3- galactosyl derivative. {ECO:0000269PubMed:8611500}.

Subcellular Localization

Golgi apparatus, Golgi stack membrane; Single-pass type II membrane protein. Secreted. Note=Membrane- bound form in trans cisternae of Golgi. Secreted into the body fluid.

Disease Associations

Tissue Specificity

Highly expressed in adult placenta, ovary and testes.

Comments

Interactions

Number of Interactions

This gene and/or its encoded proteins are associated with 1 experimentally validated interaction(s) in this database.

Experimentally validated
Total	1 [view]
Protein-Protein	1 [view]
Protein-DNA	0
Protein-RNA	0
DNA-DNA	0
RNA-RNA	0
DNA-RNA	0

Gene Ontology

Molecular Function

Accession	GO Term
GO:0008373	sialyltransferase activity

Biological Process

GO:0005975	carbohydrate metabolic process
GO:0006486	protein glycosylation
GO:0016266	O-glycan processing
GO:0018146	keratan sulfate biosynthetic process
GO:0018279	protein N-linked glycosylation via asparagine
GO:0030203	glycosaminoglycan metabolic process
GO:0042339	keratan sulfate metabolic process
GO:0043687	post-translational protein modification
GO:0044267	cellular protein metabolic process
GO:0044281	small molecule metabolic process
GO:0050890	cognition
GO:0097503	sialylation

Cellular Component

GO:0000139	Golgi membrane
GO:0005794	Golgi apparatus
GO:0016020	membrane
GO:0016021	integral component of membrane
GO:0030173	integral component of Golgi membrane
GO:0032580	Golgi cisterna membrane
GO:0070062	extracellular vesicular exosome