InnateDB: Systems Biology of the Innate Immune Response

Homo sapiens Protein: PDE11A

Summary

InnateDB Protein

IDBP-75904.7

Last Modified

2014-10-13 [Report errors or provide feedback]

Gene Symbol

PDE11A

Protein Name

phosphodiesterase 11A

Synonyms

Species

Homo sapiens

Ensembl Protein

ENSP00000351232

InnateDB Gene

IDBG-75902 (PDE11A)

Protein Structure

UniProt Annotation

Function

Plays a role in signal transduction by regulating the intracellular concentration of cyclic nucleotides cAMP and cGMP. Catalyzes the hydrolysis of both cAMP and cGMP to 5'-AMP and 5'- GMP, respectively. {ECO:0000269PubMed:10725373, ECO:0000269PubMed:10906126, ECO:0000269PubMed:11050148}.

Subcellular Localization

Cytoplasm, cytosol {ECO:0000269PubMed:10906126}.

Disease Associations

Primary pigmented nodular adrenocortical disease 2 (PPNAD2) [MIM:610475]: A rare bilateral adrenal defect causing ACTH-independent Cushing syndrome. Macroscopic appearance of the adrenals is characteristic with small pigmented micronodules observed in the cortex. Adrenal glands show overall normal size and weight, and multiple small yellow-to-dark brown nodules surrounded by a cortex with a uniform appearance. Microscopically, there are moderate diffuse cortical hyperplasia with mostly nonpigmented nodules, multiple capsular deficits and massive circumscribed and infiltrating extra-adrenal cortical excrescences with micronodules. Clinical manifestations of Cushing syndrome include facial and truncal obesity, abdominal striae, muscular weakness, osteoporosis, arterial hypertension, diabetes. {ECO:0000269PubMed:16767104}. Note=The disease is caused by mutations affecting the gene represented in this entry.

Tissue Specificity

Isoform 1 is present in prostate, pituitary, heart and liver. It is however not present in testis nor in penis, suggesting that weak inhibition by Tadalafil (Cialis) is not relevant (at protein level). Isoform 2 may be expressed in testis. Isoform 4 is expressed in adrenal cortex. {ECO:0000269PubMed:10725373, ECO:0000269PubMed:11121118, ECO:0000269PubMed:15800651, ECO:0000269PubMed:16079899, ECO:0000269PubMed:16767104}.

Comments

Interactions

Number of Interactions

This gene and/or its encoded proteins are associated with 1 experimentally validated interaction(s) in this database.

Experimentally validated
Total	1 [view]
Protein-Protein	0
Protein-DNA	1 [view]
Protein-RNA	0
DNA-DNA	0
RNA-RNA	0
DNA-RNA	0

Gene Ontology

Molecular Function

Accession	GO Term
GO:0004112	cyclic-nucleotide phosphodiesterase activity
GO:0004114	3',5'-cyclic-nucleotide phosphodiesterase activity
GO:0004118	cGMP-stimulated cyclic-nucleotide phosphodiesterase activity
GO:0005515	protein binding
GO:0030553	cGMP binding
GO:0046872	metal ion binding
GO:0047555	3',5'-cyclic-GMP phosphodiesterase activity

Biological Process

GO:0007165	signal transduction
GO:0007596	blood coagulation

Cellular Component

GO:0005575	cellular_component
GO:0005829	cytosol

Protein Structure and Domains

PDB ID

InterPro

IPR002073 3\'5\'-cyclic nucleotide phosphodiesterase, catalytic domain
IPR003018 GAF domain
IPR003607 HD/PDEase domain
IPR023088 3\'5\'-cyclic nucleotide phosphodiesterase
IPR029016 GAF domain-like

PFAM

PF00233
PF01590
PF13185
PF13492

PRINTS

PR00387

PIRSF

SMART

SM00065
SM00471

TIGRFAMs

Post-translational Modifications

Modification

Cross-References

SwissProt