InnateDB: Systems Biology of the Innate Immune Response

Homo sapiens Gene: PDE11A

Summary

InnateDB Gene

IDBG-75902.6

Last Modified

2014-10-13 [Report errors or provide feedback]

Gene Symbol

PDE11A

Gene Name

phosphodiesterase 11A

Synonyms

Species

Homo sapiens

Ensembl Gene

ENSG00000128655

Encoded Proteins

IDBP-75904

phosphodiesterase 11A

IDBP-75906

phosphodiesterase 11A

IDBP-75908

phosphodiesterase 11A

IDBP-293493

phosphodiesterase 11A

IDBP-387774

phosphodiesterase 11A

IDBP-387776

phosphodiesterase 11A

IDBP-387777

phosphodiesterase 11A

Protein Structure

Useful resources

Stemformatics EHFPI ImmGen

Entrez Gene

Summary

The 3',5'-cyclic nucleotides cAMP and cGMP function as second messengers in a wide variety of signal transduction pathways. 3',5'-cyclic nucleotide phosphodiesterases (PDEs) catalyze the hydrolysis of cAMP and cGMP to the corresponding 5'-monophosphates and provide a mechanism to downregulate cAMP and cGMP signaling. This gene encodes a member of the PDE protein superfamily. Mutations in this gene are a cause of Cushing disease and adrenocortical hyperplasia. Multiple transcript variants encoding different isoforms have been found for this gene. [provided by RefSeq, Jul 2008]

Gene Information

Type

Protein coding

Genomic Location

Chromosome 2:177623252-178108339

Strand

Reverse strand

Band

q31.2

Transcripts

ENST00000358450	ENSP00000351232
ENST00000286063	ENSP00000286063
ENST00000389683	ENSP00000374333
ENST00000409504	ENSP00000386539
ENST00000436700	ENSP00000406922
ENST00000433879	ENSP00000416884
ENST00000427127	ENSP00000389777
ENST00000478646
ENST00000488399
ENST00000466790
ENST00000497003
ENST00000492761

Interactions

Number of Interactions

This gene and/or its encoded proteins are associated with 1 experimentally validated interaction(s) in this database.

Experimentally validated
Total	1 [view]
Protein-Protein	0
Protein-DNA	1 [view]
Protein-RNA	0
DNA-DNA	0
RNA-RNA	0
DNA-RNA	0

Gene Ontology

Molecular Function

Accession	GO Term
GO:0004112	cyclic-nucleotide phosphodiesterase activity
GO:0004114	3',5'-cyclic-nucleotide phosphodiesterase activity
GO:0004118	cGMP-stimulated cyclic-nucleotide phosphodiesterase activity
GO:0005515	protein binding
GO:0030552	cAMP binding
GO:0030553	cGMP binding
GO:0046872	metal ion binding
GO:0047555	3',5'-cyclic-GMP phosphodiesterase activity

Biological Process

GO:0006198	cAMP catabolic process
GO:0007165	signal transduction
GO:0007596	blood coagulation
GO:0046069	cGMP catabolic process

Cellular Component

GO:0005575	cellular_component
GO:0005829	cytosol
GO:0043204	perikaryon

Orthologs

Species

Mus musculus

Bos taurus

Gene ID

Gene Order

ENSMUSG00000075270

View Gene Order

ENSBTAG00000016396

Not yet available

Pathways

NETPATH

REACTOME

REACT_23767

cGMP effects pathway

REACT_23862

Nitric oxide stimulates guanylate cyclase pathway

REACT_23876

Platelet homeostasis pathway

REACT_19327

G alpha (s) signalling events pathway

REACT_14797

Signaling by GPCR pathway

REACT_111102

Signal Transduction pathway

REACT_19184

GPCR downstream signaling pathway

REACT_604

Hemostasis pathway

KEGG

hsa00230

Purine metabolism pathway

INOH

PID NCI

Cross-References

SwissProt

TrEMBL

UniProt Splice Variant

Entrez Gene

UniGene

Hs.570273

RefSeq

NM_001077196 NM_001077197 NM_001077358 NM_016953

HUGO

OMIM

CCDS

CCDS33334 CCDS42785 CCDS42786 CCDS46459

HPRD

05391

IMGT

EMBL

GenPept

RNA Seq Atlas