InnateDB Protein
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IDBP-759706.3
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Last Modified
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2014-10-13 [Report errors or provide feedback]
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Gene Symbol
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RNF43
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Protein Name
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Synonyms
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Species
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Homo sapiens
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Ensembl Protein
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ENSP00000463716
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InnateDB Gene
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IDBG-61124 (RNF43)
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Protein Structure
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Function |
E3 ubiquitin-protein ligase that acts as a negative regulator of the Wnt signaling pathway by mediating the ubiquitination, endocytosis and subsequent degradation of Wnt receptor complex components Frizzled. Acts on both canonical and non-canonical Wnt signaling pathway. Acts as a tumor suppressor in the intestinal stem cell zone by inhibiting the Wnt signaling pathway, thereby resticting the size of the intestinal stem cell zone. {ECO:0000269PubMed:18313049, ECO:0000269PubMed:22575959, ECO:0000269PubMed:22895187}.
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Subcellular Localization |
Cell membrane; Single-pass type I membrane protein. Endoplasmic reticulum membrane; Single-pass type I membrane protein. Nucleus envelope. Note=According to a report, may be secreted. {ECO:0000269PubMed:15492824}.
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Disease Associations |
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Tissue Specificity |
Expressed in fetal kidney, fetal lung, in colon cancer tissues, hepatocellular carcinomas and lung adenocarcinomas. Overexpressed in colorectal cancer cell lines. {ECO:0000269PubMed:15492824, ECO:0000269PubMed:18313049}.
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Comments |
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Number of Interactions
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This gene and/or its encoded proteins are associated with 17 experimentally validated interaction(s) in this database.
Experimentally validated |
Total |
17
[view]
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Protein-Protein |
17
[view]
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Protein-DNA |
0
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Protein-RNA |
0
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DNA-DNA |
0
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RNA-RNA |
0
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DNA-RNA |
0
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Molecular Function |
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Biological Process |
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Cellular Component |
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PDB ID |
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InterPro |
IPR001841
Zinc finger, RING-type
IPR018957
Zinc finger, C3HC4 RING-type
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PFAM |
PF13639
PF14634
PF00097
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PRINTS |
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PIRSF |
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SMART |
SM00184
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TIGRFAMs |
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Modification |
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SwissProt |
Q68DV7
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PhosphoSite |
PhosphoSite-Q68DV7
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TrEMBL |
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UniProt Splice Variant |
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Entrez Gene |
54894
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UniGene |
Hs.688837
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RefSeq |
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HUGO |
HGNC:18505
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OMIM |
612482
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CCDS |
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HPRD |
07896
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IMGT |
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EMBL |
AB081837
AK000322
AK291027
AK296769
AK298789
AK299024
BC109028
CR627423
CR749257
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GenPept |
AAI09029
BAA91085
BAD51435
BAF83716
BAH12429
BAH12871
BAH12931
CAH10510
CAH18113
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