Version 5.4
Homo sapiens Protein: KLK8
Summary
InnateDB Protein IDBP-759743.3
Last Modified 2014-10-13 [Report errors or provide feedback]
Gene Symbol KLK8
Protein Name
Synonyms HNP; NP; NRPN; PRSS19; TADG14;
Species Homo sapiens
Ensembl Protein ENSP00000469278
InnateDB Gene IDBG-65297 (KLK8)
Protein Structure
UniProt Annotation
Function
Subcellular Localization
Disease Associations
Tissue Specificity
Comments
Interactions
Number of Interactions This gene and/or its encoded proteins are associated with 2 experimentally validated interaction(s) in this database.
They are also associated with 1 interaction(s) predicted by orthology.
Experimentally validated
Total 2 [view]
Protein-Protein 2 [view]
Protein-DNA 0
Protein-RNA 0
DNA-DNA 0
RNA-RNA 0
DNA-RNA 0
Predicted by orthology
Total 1 [view]
Gene Ontology

Molecular Function
Accession GO Term
GO:0004252 serine-type endopeptidase activity
GO:0005515 protein binding
Biological Process
GO:0006508 proteolysis
GO:0007613 memory
GO:0008219 cell death
GO:0009611 response to wounding
GO:0031642 negative regulation of myelination
GO:0043616 keratinocyte proliferation
GO:0048681 negative regulation of axon regeneration
GO:0048812 neuron projection morphogenesis
GO:0050807 regulation of synapse organization
Cellular Component
GO:0005615 extracellular space
GO:0005737 cytoplasm
Protein Structure and Domains
PDB ID
InterPro
PFAM
PRINTS
PIRSF
SMART
TIGRFAMs
Post-translational Modifications
Modification
Cross-References
SwissProt O60259
PhosphoSite PhosphoSite-
TrEMBL
UniProt Splice Variant
Entrez Gene 11202
UniGene Hs.104570
RefSeq
HUGO HGNC:6369
OMIM 605644
CCDS CCDS12815
HPRD 05733
IMGT
EMBL AB008390 AB008927 AB009849 AB010780 AB012761 AC011473 AC011483 AF055982 AF095742 AF095743 AF243527 AF251125 AY359036 AY563055 AY563056 AY563057 AY563058 AY563059 AY563060 AY563061 AY563062 AY563063 AY563064 AY563065 AY563066 AY563067 BC040887 CH471135 DQ267420
GenPept AAD25979 AAD29574 AAD56050 AAF79144 AAF79145 AAG23254 AAG33361 AAH40887 AAQ89395 AAT76913 AAT76914 AAT76915 AAT76916 AAT76917 AAT76918 AAT76919 AAT76920 AAT76921 AAT76922 AAT76923 AAT76924 AAT76925 AAT76926 AAT76927 AAT76928 AAT76929 AAT76930 AAT76931 AAT76932 AAT76933 AAT76934 AAT76935 AAT76936 AAT76937 AAT76938 ABB83339 BAA28673 BAA28676 BAA82665 BAA82666 BAA88684 EAW71962

If you use InnateDB for your research, please cite the following publication:

Breuer et al., InnateDB: systems biology of innate immunity and beyond - recent updates and continuing curation. Nucl. Acids Res. (2013) 41 (D1) 

InnateDB is being developed jointly by the Brinkman Laboratory (Simon Fraser University, British Columbia, Canada), the Hancock Laboratory (University of British Columbia, Vancouver, British Columbia) and the Lynn EMBL Australia Group (South Australian Health & Medical Research Institute and Flinders University, Adelaide, Australia).

Funding is currently provided by Allergen and EMBL Australia. Previous funding has been provided by Genome Canada, the Foundation for the National Institutes of Health through the Grand Challenges in Global Health initiative and by Teagasc. InnateDB curated interactions are licensed under the Design Science License. All other data is licensed under the terms of the originating database. Contact: innatedb-mail@sfu.ca