Version 5.4
Homo sapiens Protein: TOP2A
Summary
InnateDB Protein IDBP-760056.3
Last Modified 2014-10-13 [Report errors or provide feedback]
Gene Symbol TOP2A
Protein Name
Synonyms TOP2; TP2A;
Species Homo sapiens
Ensembl Protein ENSP00000462908
InnateDB Gene IDBG-47552 (TOP2A)
Protein Structure
UniProt Annotation
Function
Subcellular Localization
Disease Associations
Tissue Specificity
Comments
Interactions
Number of Interactions This gene and/or its encoded proteins are associated with 88 experimentally validated interaction(s) in this database.
They are also associated with 10 interaction(s) predicted by orthology.
Experimentally validated
Total 88 [view]
Protein-Protein 81 [view]
Protein-DNA 7 [view]
Protein-RNA 0
DNA-DNA 0
RNA-RNA 0
DNA-RNA 0
Predicted by orthology
Total 10 [view]
Gene Ontology

Molecular Function
Accession GO Term
GO:0000287 magnesium ion binding
GO:0005524 ATP binding
GO:0008301 DNA binding, bending
Biological Process
GO:0006200 ATP catabolic process
Cellular Component
Protein Structure and Domains
PDB ID
InterPro IPR001241 DNA topoisomerase, type IIA
IPR003594 Histidine kinase-like ATPase, C-terminal domain
PFAM PF02518
PF13581
PRINTS PR00418
PIRSF
SMART SM00433
SM00387
TIGRFAMs
Post-translational Modifications
Modification
Cross-References
SwissProt
PhosphoSite PhosphoSite-
TrEMBL J3KTB7
UniProt Splice Variant
Entrez Gene 7153
UniGene Hs.654618
RefSeq
HUGO HGNC:11989
OMIM 126430
CCDS
HPRD 00536
IMGT
EMBL AC080112
GenPept

If you use InnateDB for your research, please cite the following publication:

Breuer et al., InnateDB: systems biology of innate immunity and beyond - recent updates and continuing curation. Nucl. Acids Res. (2013) 41 (D1) 

InnateDB is being developed jointly by the Brinkman Laboratory (Simon Fraser University, British Columbia, Canada), the Hancock Laboratory (University of British Columbia, Vancouver, British Columbia) and the Lynn EMBL Australia Group (South Australian Health & Medical Research Institute and Flinders University, Adelaide, Australia).

Funding is currently provided by Allergen and EMBL Australia. Previous funding has been provided by Genome Canada, the Foundation for the National Institutes of Health through the Grand Challenges in Global Health initiative and by Teagasc. InnateDB curated interactions are licensed under the Design Science License. All other data is licensed under the terms of the originating database. Contact: innatedb-mail@sfu.ca