InnateDB: Systems Biology of the Innate Immune Response

Homo sapiens Protein: HDAC5

Summary

InnateDB Protein

IDBP-760073.3

Last Modified

2014-10-13 [Report errors or provide feedback]

Gene Symbol

HDAC5

Protein Name

Synonyms

HD5; NY-CO-9;

Species

Homo sapiens

Ensembl Protein

ENSP00000468004

InnateDB Gene

IDBG-53295 (HDAC5)

Protein Structure

UniProt Annotation

Function

Subcellular Localization

Disease Associations

Tissue Specificity

Comments

Interactions

Number of Interactions

This gene and/or its encoded proteins are associated with 368 experimentally validated interaction(s) in this database.
They are also associated with 13 interaction(s) predicted by orthology.

Experimentally validated
Total	368 [view]
Protein-Protein	365 [view]
Protein-DNA	2 [view]
Protein-RNA	0
DNA-DNA	1 [view]
RNA-RNA	0
DNA-RNA	0

Predicted by orthology
Total	13 [view]

Gene Ontology

Molecular Function

Accession	GO Term
GO:0004407	histone deacetylase activity
GO:0005080	protein kinase C binding
GO:0005515	protein binding
GO:0008134	transcription factor binding
GO:0032041	NAD-dependent histone deacetylase activity (H3-K14 specific)
GO:0044212	transcription regulatory region DNA binding
GO:0046872	metal ion binding
GO:0046969	NAD-dependent histone deacetylase activity (H3-K9 specific)
GO:0046970	NAD-dependent histone deacetylase activity (H4-K16 specific)
GO:0070491	repressing transcription factor binding
GO:0097372	NAD-dependent histone deacetylase activity (H3-K18 specific)

Biological Process

GO:0000122	negative regulation of transcription from RNA polymerase II promoter
GO:0006325	chromatin organization
GO:0006338	chromatin remodeling
GO:0006342	chromatin silencing
GO:0006351	transcription, DNA-templated
GO:0006954	inflammatory response
GO:0007219	Notch signaling pathway
GO:0010830	regulation of myotube differentiation
GO:0010832	negative regulation of myotube differentiation
GO:0016568	chromatin modification
GO:0016575	histone deacetylation
GO:0030183	B cell differentiation
GO:0032869	cellular response to insulin stimulus
GO:0042113	B cell activation
GO:0043393	regulation of protein binding
GO:0045892	negative regulation of transcription, DNA-templated
GO:0045944	positive regulation of transcription from RNA polymerase II promoter
GO:0051091	positive regulation of sequence-specific DNA binding transcription factor activity
GO:0070932	histone H3 deacetylation
GO:0070933	histone H4 deacetylation
GO:0090051	negative regulation of cell migration involved in sprouting angiogenesis

Cellular Component

GO:0000118	histone deacetylase complex
GO:0005634	nucleus
GO:0005654	nucleoplasm
GO:0005737	cytoplasm
GO:0005794	Golgi apparatus

Protein Structure and Domains

PDB ID

InterPro

IPR000286 Histone deacetylase superfamily
IPR017320 Histone deacetylase class II, eukaryotic
IPR023801 Histone deacetylase domain
IPR024643 Histone deacetylase, glutamine rich N-terminal domain

PFAM

PF00850
PF12203

PRINTS

PR01270

PIRSF

PIRSF037911

SMART

TIGRFAMs

Post-translational Modifications

Modification

Cross-References

SwissProt