InnateDB: Systems Biology of the Innate Immune Response

Homo sapiens Protein: TAF1

Summary

InnateDB Protein

IDBP-76061.7

Last Modified

2014-10-13 [Report errors or provide feedback]

Gene Symbol

TAF1

Protein Name

TAF1 RNA polymerase II, TATA box binding protein (TBP)-associated factor, 250kDa

Synonyms

BA2R; CCG1; CCGS; DYT3; DYT3/TAF1; KAT4; N-TAF1; NSCL2; OF; P250; TAF(II)250; TAF2A; TAFII-250; TAFII250; XDP;

Species

Homo sapiens

Ensembl Protein

ENSP00000276072

InnateDB Gene

IDBG-76057 (TAF1)

Protein Structure

UniProt Annotation

Function

Largest component and core scaffold of the TFIID basal transcription factor complex. Contains novel N- and C-terminal Ser/Thr kinase domains which can autophosphorylate or transphosphorylate other transcription factors. Phosphorylates TP53 on 'Thr-55' which leads to MDM2-mediated degradation of TP53. Phosphorylates GTF2A1 and GTF2F1 on Ser residues. Possesses DNA- binding activity. Essential for progression of the G1 phase of the cell cycle. Exhibits histone acetyltransferase activity towards histones H3 and H4. {ECO:0000269PubMed:11278496, ECO:0000269PubMed:15053879, ECO:0000269PubMed:2038334, ECO:0000269PubMed:8450888, ECO:0000269PubMed:8625415, ECO:0000269PubMed:9660973, ECO:0000269PubMed:9858607}.

Subcellular Localization

Nucleus {ECO:0000269PubMed:2038334}.

Disease Associations

Dystonia 3, torsion, X-linked (DYT3) [MIM:314250]: A X- linked dystonia-parkinsonism disorder. Dystonia is defined by the presence of sustained involuntary muscle contractions, often leading to abnormal postures. DYT3 is characterized by severe progressive torsion dystonia followed by parkinsonism. It has a well-defined pathology of extensive neuronal loss and mosaic gliosis in the striatum (caudate nucleus and putamen) which appears to resemble that in Huntington disease. {ECO:0000269PubMed:12928496, ECO:0000269PubMed:17273961}. Note=The disease is caused by mutations affecting the gene represented in this entry.

Tissue Specificity

Comments

Interactions

Number of Interactions

This gene and/or its encoded proteins are associated with 79 experimentally validated interaction(s) in this database.
They are also associated with 3 interaction(s) predicted by orthology.

Experimentally validated
Total	79 [view]
Protein-Protein	77 [view]
Protein-DNA	1 [view]
Protein-RNA	0
DNA-DNA	1 [view]
RNA-RNA	0
DNA-RNA	0

Predicted by orthology
Total	3 [view]

Gene Ontology

Molecular Function

Accession	GO Term
GO:0002039	p53 binding
GO:0003677	DNA binding
GO:0003713	transcription coactivator activity
GO:0004402	histone acetyltransferase activity
GO:0004674	protein serine/threonine kinase activity
GO:0005515	protein binding
GO:0005524	ATP binding
GO:0008134	transcription factor binding
GO:0017025	TBP-class protein binding
GO:0043565	sequence-specific DNA binding
GO:0044212	transcription regulatory region DNA binding
GO:0070577	lysine-acetylated histone binding

Biological Process

GO:0000117	regulation of transcription involved in G2/M transition of mitotic cell cycle
GO:0006352	DNA-templated transcription, initiation
GO:0006355	regulation of transcription, DNA-templated
GO:0006366	transcription from RNA polymerase II promoter
GO:0006367	transcription initiation from RNA polymerase II promoter
GO:0006368	transcription elongation from RNA polymerase II promoter
GO:0006974	cellular response to DNA damage stimulus
GO:0010467	gene expression
GO:0016032	viral process
GO:0016573	histone acetylation
GO:0018105	peptidyl-serine phosphorylation
GO:0018107	peptidyl-threonine phosphorylation
GO:0032436	positive regulation of proteasomal ubiquitin-dependent protein catabolic process
GO:0045944	positive regulation of transcription from RNA polymerase II promoter
GO:0046777	protein autophosphorylation
GO:0051123	RNA polymerase II transcriptional preinitiation complex assembly
GO:0060261	positive regulation of transcription initiation from RNA polymerase II promoter

Cellular Component

GO:0005634	nucleus
GO:0005654	nucleoplasm
GO:0005669	transcription factor TFIID complex
GO:0071339	MLL1 complex

Protein Structure and Domains

PDB ID

InterPro

IPR001487 Bromodomain
IPR009067 TAFII-230 TBP-binding
IPR011177 Transcription initiation factor TFIID subunit 1, animal
IPR022591 Transcription initiation factor TFIID subunit 1, domain of unknown function

PFAM

PF00439
PF09247
PF12157

PRINTS

PR00503

PIRSF

PIRSF003047

SMART

SM00297

TIGRFAMs

Post-translational Modifications

Modification

Cross-References