InnateDB: Systems Biology of the Innate Immune Response

Homo sapiens Protein: SLC26A11

Summary

InnateDB Protein

IDBP-761174.3

Last Modified

2014-10-13 [Report errors or provide feedback]

Gene Symbol

SLC26A11

Protein Name

Synonyms

Species

Homo sapiens

Ensembl Protein

ENSP00000459470

InnateDB Gene

IDBG-71590 (SLC26A11)

Protein Structure

UniProt Annotation

Function

Exhibits sodium-independent sulfate anion transporter activity that may cooperate with SLC26A2 to mediate DIDS-sensitive sulfate uptake into high endothelial venules endothelial cells (HEVEC). {ECO:0000269PubMed:12626430}.

Subcellular Localization

Cell membrane {ECO:0000269PubMed:12626430}; Multi-pass membrane protein {ECO:0000269PubMed:12626430}. Lysosome membrane; Multi-pass membrane protein {ECO:0000269PubMed:12626430}.

Disease Associations

Tissue Specificity

Detected in all tissues tested with highest expression observed in brain, kidney, HEVEC and placenta and lowest in pancreas, skeletal muscle, liver, lung and heart. {ECO:0000269PubMed:11087667, ECO:0000269PubMed:12626430}.

Comments

Interactions

Number of Interactions

This gene and/or its encoded proteins are associated with 1 experimentally validated interaction(s) in this database.

Experimentally validated
Total	1 [view]
Protein-Protein	1 [view]
Protein-DNA	0
Protein-RNA	0
DNA-DNA	0
RNA-RNA	0
DNA-RNA	0

Gene Ontology

Molecular Function

Accession	GO Term
GO:0008271	secondary active sulfate transmembrane transporter activity
GO:0008509	anion transmembrane transporter activity
GO:0015116	sulfate transmembrane transporter activity
GO:0015301	anion:anion antiporter activity

Biological Process

GO:0008272	sulfate transport
GO:1902358	sulfate transmembrane transport

Cellular Component

GO:0005765	lysosomal membrane
GO:0005783	endoplasmic reticulum
GO:0005794	Golgi apparatus
GO:0005886	plasma membrane
GO:0016021	integral component of membrane
GO:0070062	extracellular vesicular exosome