InnateDB: Systems Biology of the Innate Immune Response

Homo sapiens Protein: PDE4A

Summary

InnateDB Protein

IDBP-761344.3

Last Modified

2014-10-13 [Report errors or provide feedback]

Gene Symbol

PDE4A

Protein Name

Synonyms

DPDE2; PDE4; PDE46;

Species

Homo sapiens

Ensembl Protein

ENSP00000468507

InnateDB Gene

IDBG-27301 (PDE4A)

Protein Structure

UniProt Annotation

Function

Subcellular Localization

Disease Associations

Tissue Specificity

Comments

Interactions

Number of Interactions

This gene and/or its encoded proteins are associated with 9 experimentally validated interaction(s) in this database.

Experimentally validated
Total	9 [view]
Protein-Protein	8 [view]
Protein-DNA	1 [view]
Protein-RNA	0
DNA-DNA	0
RNA-RNA	0
DNA-RNA	0

Gene Ontology

Molecular Function

Accession	GO Term
GO:0004114	3',5'-cyclic-nucleotide phosphodiesterase activity
GO:0004115	3',5'-cyclic-AMP phosphodiesterase activity
GO:0005515	protein binding
GO:0030552	cAMP binding
GO:0046872	metal ion binding

Biological Process

GO:0006198	cAMP catabolic process
GO:0007165	signal transduction

Cellular Component

GO:0005829	cytosol
GO:0016020	membrane
GO:0032587	ruffle membrane
GO:0048471	perinuclear region of cytoplasm

Protein Structure and Domains

PDB ID

InterPro

IPR002073 3\'5\'-cyclic nucleotide phosphodiesterase, catalytic domain
IPR003607 HD/PDEase domain
IPR023088 3\'5\'-cyclic nucleotide phosphodiesterase

PFAM

PF00233

PRINTS

PR00387

PIRSF

SMART

SM00471

TIGRFAMs

Post-translational Modifications

Modification

Cross-References

SwissProt