Version 5.4
Homo sapiens Protein: CENPP
Summary
InnateDB Protein IDBP-76135.6
Last Modified 2014-10-13 [Report errors or provide feedback]
Gene Symbol CENPP
Protein Name centromere protein P
Synonyms
Species Homo sapiens
Ensembl Protein ENSP00000364737
InnateDB Gene IDBG-76133 (CENPP)
Protein Structure
UniProt Annotation
Function Component of the CENPA-CAD (nucleosome distal) complex, a complex recruited to centromeres which is involved in assembly of kinetochore proteins, mitotic progression and chromosome segregation. May be involved in incorporation of newly synthesized CENPA into centromeres via its interaction with the CENPA-NAC complex. {ECO:0000269PubMed:16622420}.
Subcellular Localization Nucleus {ECO:0000269PubMed:16622420}. Chromosome, centromere {ECO:0000269PubMed:16622420}. Note=Localizes exclusively in the centromeres. The CENPA-CAD complex is probably recruited on centromeres by the CENPA-NAC complex.
Disease Associations
Tissue Specificity
Comments
Interactions
Number of Interactions This gene and/or its encoded proteins are associated with 9 experimentally validated interaction(s) in this database.
Experimentally validated
Total 9 [view]
Protein-Protein 9 [view]
Protein-DNA 0
Protein-RNA 0
DNA-DNA 0
RNA-RNA 0
DNA-RNA 0
Gene Ontology

Molecular Function
Accession GO Term
Biological Process
GO:0000278 mitotic cell cycle
GO:0006334 nucleosome assembly
GO:0034080 centromere-specific nucleosome assembly
Cellular Component
GO:0000775 chromosome, centromeric region
GO:0005654 nucleoplasm
GO:0005829 cytosol
Protein Structure and Domains
PDB ID
InterPro
PFAM
PRINTS
PIRSF
SMART
TIGRFAMs
Post-translational Modifications
Modification
Cross-References
SwissProt Q6IPU0
PhosphoSite PhosphoSite-Q6IPU0
TrEMBL
UniProt Splice Variant
Entrez Gene 401541
UniGene Hs.713775
RefSeq NP_001273898
HUGO HGNC:32933
OMIM 611505
CCDS CCDS35063
HPRD 17989
IMGT
EMBL AK091247 AK092603 AL136097 AL137848 AL157827 BC071726
GenPept AAH71726 BAG52317 BAG52579 CAI12591 CAI12592 CAI12594 CAI16210 CAI16699

If you use InnateDB for your research, please cite the following publication:

Breuer et al., InnateDB: systems biology of innate immunity and beyond - recent updates and continuing curation. Nucl. Acids Res. (2013) 41 (D1) 

InnateDB is being developed jointly by the Brinkman Laboratory (Simon Fraser University, British Columbia, Canada), the Hancock Laboratory (University of British Columbia, Vancouver, British Columbia) and the Lynn EMBL Australia Group (South Australian Health & Medical Research Institute and Flinders University, Adelaide, Australia).

Funding is currently provided by Allergen and EMBL Australia. Previous funding has been provided by Genome Canada, the Foundation for the National Institutes of Health through the Grand Challenges in Global Health initiative and by Teagasc. InnateDB curated interactions are licensed under the Design Science License. All other data is licensed under the terms of the originating database. Contact: innatedb-mail@sfu.ca