InnateDB Protein
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IDBP-76139.6
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Last Modified
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2014-10-13 [Report errors or provide feedback]
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Gene Symbol
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CENPP
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Protein Name
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centromere protein P
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Synonyms
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Species
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Homo sapiens
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Ensembl Protein
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ENSP00000364726
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InnateDB Gene
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IDBG-76133 (CENPP)
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Protein Structure
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Function |
Component of the CENPA-CAD (nucleosome distal) complex, a complex recruited to centromeres which is involved in assembly of kinetochore proteins, mitotic progression and chromosome segregation. May be involved in incorporation of newly synthesized CENPA into centromeres via its interaction with the CENPA-NAC complex. {ECO:0000269PubMed:16622420}.
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Subcellular Localization |
Nucleus {ECO:0000269PubMed:16622420}. Chromosome, centromere {ECO:0000269PubMed:16622420}. Note=Localizes exclusively in the centromeres. The CENPA-CAD complex is probably recruited on centromeres by the CENPA-NAC complex.
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Disease Associations |
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Tissue Specificity |
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Comments |
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Number of Interactions
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This gene and/or its encoded proteins are associated with 9 experimentally validated interaction(s) in this database.
Experimentally validated |
Total |
9
[view]
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Protein-Protein |
9
[view]
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Protein-DNA |
0
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Protein-RNA |
0
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DNA-DNA |
0
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RNA-RNA |
0
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DNA-RNA |
0
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Molecular Function |
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Biological Process |
GO:0034080
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centromere-specific nucleosome assembly
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Cellular Component |
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PDB ID |
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InterPro |
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PFAM |
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PRINTS |
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PIRSF |
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SMART |
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TIGRFAMs |
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Modification |
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SwissProt |
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PhosphoSite |
PhosphoSite-Q6IPU0
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TrEMBL |
X6R9C8
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UniProt Splice Variant |
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Entrez Gene |
401541
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UniGene |
Hs.713775
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RefSeq |
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HUGO |
HGNC:32933
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OMIM |
611505
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CCDS |
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HPRD |
17989
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IMGT |
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EMBL |
AL136097
AL137848
AL157827
CH471089
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GenPept |
EAW62825
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