InnateDB Protein
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IDBP-761505.3
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Last Modified
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2014-10-13 [Report errors or provide feedback]
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Gene Symbol
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ATP2A3
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Protein Name
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Synonyms
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SERCA3;
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Species
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Homo sapiens
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Ensembl Protein
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ENSP00000461480
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InnateDB Gene
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IDBG-18252 (ATP2A3)
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Protein Structure
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Function |
This magnesium-dependent enzyme catalyzes the hydrolysis of ATP coupled with the transport of calcium. Transports calcium ions from the cytosol into the sarcoplasmic/endoplasmic reticulum lumen. Contributes to calcium sequestration involved in muscular excitation/contraction. {ECO:0000269PubMed:11956212, ECO:0000269PubMed:15028735}.
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Subcellular Localization |
Nucleus membrane {ECO:0000269PubMed:15028735}; Multi-pass membrane protein {ECO:0000269PubMed:15028735}. Endoplasmic reticulum membrane {ECO:0000269PubMed:15028735}; Multi-pass membrane protein {ECO:0000269PubMed:15028735}. Sarcoplasmic reticulum membrane {ECO:0000269PubMed:15028735}; Multi-pass membrane protein {ECO:0000269PubMed:15028735}.
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Disease Associations |
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Tissue Specificity |
Found in most tissues. Most abundant in thymus, trachea, salivary gland, spleen, bone marrow, lymph node, peripheral leukocytes, pancreas and colon. Also detected in fetal tissues. Expressed in cell lineages of hematopoietic, epithelial, or embryonic origin and also expressed in several cancer cell lines. {ECO:0000269PubMed:11956212, ECO:0000269PubMed:15028735}.
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Comments |
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Number of Interactions
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This gene and/or its encoded proteins are associated with 10 experimentally validated interaction(s) in this database.
Experimentally validated |
Total |
10
[view]
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Protein-Protein |
10
[view]
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Protein-DNA |
0
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Protein-RNA |
0
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DNA-DNA |
0
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RNA-RNA |
0
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DNA-RNA |
0
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Molecular Function |
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Biological Process |
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Cellular Component |
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PDB ID |
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InterPro |
IPR006068
Cation-transporting P-type ATPase, C-terminal
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PFAM |
PF00689
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PRINTS |
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PIRSF |
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SMART |
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TIGRFAMs |
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Modification |
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SwissProt |
Q93084
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PhosphoSite |
PhosphoSite-Q93084
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TrEMBL |
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UniProt Splice Variant |
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Entrez Gene |
489
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UniGene |
Hs.513870
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RefSeq |
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HUGO |
HGNC:813
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OMIM |
601929
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CCDS |
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HPRD |
03568
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IMGT |
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EMBL |
AC005940
AF068220
AF068221
AF458228
AF458229
AY460339
BC035729
CH471108
S68239
Y15724
Y15725
Y15726
Y15727
Y15728
Y15729
Y15730
Y15737
Y15738
Z69880
Z69881
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GenPept |
AAB29700
AAC24525
AAC24526
AAH35729
AAL78967
AAL78968
AAR15415
CAA75739
CAA75747
CAA75748
CAA93736
CAA93737
EAW90463
EAW90468
EAW90469
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