InnateDB Protein
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IDBP-76163.6
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Last Modified
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2014-10-13 [Report errors or provide feedback]
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Gene Symbol
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DDR1
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Protein Name
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discoidin domain receptor tyrosine kinase 1
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Synonyms
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CAK; CD167; DDR; EDDR1; HGK2; MCK10; NEP; NTRK4; PTK3; PTK3A; RTK6; TRKE;
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Species
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Homo sapiens
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Ensembl Protein
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ENSP00000365759
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InnateDB Gene
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IDBG-76157 (DDR1)
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Protein Structure
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Function |
Tyrosine kinase that functions as cell surface receptor for fibrillar collagen and regulates cell attachment to the extracellular matrix, remodeling of the extracellular matrix, cell migration, differentiation, survival and cell proliferation. Collagen binding triggers a signaling pathway that involves SRC and leads to the activation of MAP kinases. Regulates remodeling of the extracellular matrix by up-regulation of the matrix metalloproteinases MMP2, MMP7 and MMP9, and thereby facilitates cell migration and wound healing. Required for normal blastocyst implantation during pregnancy, for normal mammary gland differentiation and normal lactation. Required for normal ear morphology and normal hearing (By similarity). Promotes smooth muscle cell migration, and thereby contributes to arterial wound healing. Also plays a role in tumor cell invasion. Phosphorylates PTPN11. {ECO:0000250, ECO:0000269PubMed:12065315, ECO:0000269PubMed:16234985, ECO:0000269PubMed:16337946, ECO:0000269PubMed:19401332, ECO:0000269PubMed:20093046, ECO:0000269PubMed:20432435, ECO:0000269PubMed:20884741, ECO:0000269PubMed:21044884, ECO:0000269PubMed:9659899}.
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Subcellular Localization |
Isoform 1: Cell membrane; Single-pass type I membrane protein.Isoform 2: Cell membrane; Single-pass type I membrane protein.Isoform 3: Secreted {ECO:0000305}.Isoform 4: Cell membrane; Single-pass type I membrane protein.
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Disease Associations |
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Tissue Specificity |
Detected in T-47D, MDA-MB-175 and HBL-100 breast carcinoma cells, A-431 epidermoid carcinoma cells, SW48 and SNU-C2B colon carcinoma cells and Hs 294T melanoma cells (at protein level). Expressed at low levels in most adult tissues and is highest in the brain, lung, placenta and kidney. Lower levels of expression are detected in melanocytes, heart, liver, skeletal muscle and pancreas. Abundant in breast carcinoma cell lines. In the colonic mucosa, expressed in epithelia but not in the connective tissue of the lamina propria. In the thyroid gland, expressed in the epithelium of the thyroid follicles. In pancreas, expressed in the islets of Langerhans cells, but not in the surrounding epithelial cells of the exocrine pancreas. In kidney, expressed in the epithelia of the distal tubules. Not expressed in connective tissue, endothelial cells, adipose tissue, muscle cells or cells of hematopoietic origin. {ECO:0000269PubMed:7845687, ECO:0000269PubMed:7848919, ECO:0000269PubMed:8247543}.
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Comments |
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Number of Interactions
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This gene and/or its encoded proteins are associated with 19 experimentally validated interaction(s) in this database.
They are also associated with 1 interaction(s) predicted by orthology.
Experimentally validated |
Total |
19
[view]
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Protein-Protein |
19
[view]
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Protein-DNA |
0
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Protein-RNA |
0
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DNA-DNA |
0
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RNA-RNA |
0
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DNA-RNA |
0
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Predicted by orthology |
Total |
1 [view]
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Molecular Function |
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Biological Process |
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Cellular Component |
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PDB ID |
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InterPro |
IPR000421
Coagulation factor 5/8 C-terminal type domain
IPR008979
Galactose-binding domain-like
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PFAM |
PF00754
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PRINTS |
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PIRSF |
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SMART |
SM00231
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TIGRFAMs |
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Modification |
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SwissProt |
Q08345
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PhosphoSite |
PhosphoSite-Q08345
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TrEMBL |
E7EXB0
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UniProt Splice Variant |
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Entrez Gene |
780
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UniGene |
Hs.739208
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RefSeq |
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HUGO |
HGNC:2730
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OMIM |
600408
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CCDS |
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HPRD |
02678
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IMGT |
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EMBL |
AB088102
AB103608
AB202100
AB210021
AK291621
AK294793
AL662854
AL662870
AL773541
AL773589
BA000025
BC008716
BC013400
BC070070
BX927194
CH471081
CR759747
EU826613
EU826614
L11315
L20817
L57508
U48705
X74979
X98208
X99023
X99024
X99025
X99026
X99027
X99028
X99029
X99030
X99031
X99032
X99033
X99034
Z29093
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GenPept |
AAA02866
AAA18019
AAB05208
AAC50917
AAH08716
AAH13400
AAH70070
ACF47649
ACF47650
BAB63318
BAC54935
BAE06103
BAE78621
BAF31270
BAF84310
BAH11886
CAA52915
CAA66871
CAA82335
CAI17433
CAI17434
CAI18441
CAI18442
CAI18450
CAI18451
CAI18533
CAI18534
CAQ06756
CAQ06757
CAQ09767
CAQ09768
EAX03335
EAX03338
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