InnateDB: Systems Biology of the Innate Immune Response

Homo sapiens Protein: APLP2

Summary

InnateDB Protein

IDBP-76183.6

Last Modified

2014-10-13 [Report errors or provide feedback]

Gene Symbol

APLP2

Protein Name

amyloid beta (A4) precursor-like protein 2

Synonyms

APLP-2; APPH; APPL2; CDEBP;

Species

Homo sapiens

Ensembl Protein

ENSP00000263574

InnateDB Gene

IDBG-76181 (APLP2)

Protein Structure

UniProt Annotation

Function

May play a role in the regulation of hemostasis. The soluble form may have inhibitory properties towards coagulation factors. May interact with cellular G-protein signaling pathways. May bind to the DNA 5'-GTCACATG-3'(CDEI box). Inhibits trypsin, chymotrypsin, plasmin, factor XIA and plasma and glandular kallikrein. Modulates the Cu/Zn nitric oxide-catalyzed autodegradation of GPC1 heparan sulfate side chains in fibroblasts (By similarity). {ECO:0000250}.

Subcellular Localization

Cell membrane {ECO:0000305}; Single-pass type I membrane protein {ECO:0000305}. Nucleus {ECO:0000305}.

Disease Associations

Tissue Specificity

Expressed in placenta, brain, heart, lung, liver, kidney and endothelial tissues.

Comments

Interactions

Number of Interactions

This gene and/or its encoded proteins are associated with 31 experimentally validated interaction(s) in this database.
They are also associated with 7 interaction(s) predicted by orthology.

Experimentally validated
Total	31 [view]
Protein-Protein	31 [view]
Protein-DNA	0
Protein-RNA	0
DNA-DNA	0
RNA-RNA	0
DNA-RNA	0

Predicted by orthology
Total	7 [view]

Gene Ontology

Molecular Function

Accession	GO Term
GO:0003677	DNA binding
GO:0004867	serine-type endopeptidase inhibitor activity
GO:0005515	protein binding
GO:0008201	heparin binding
GO:0042802	identical protein binding
GO:0046914	transition metal ion binding

Biological Process

GO:0001967	suckling behavior
GO:0006878	cellular copper ion homeostasis
GO:0007176	regulation of epidermal growth factor-activated receptor activity
GO:0007186	G-protein coupled receptor signaling pathway
GO:0007617	mating behavior
GO:0007626	locomotory behavior
GO:0008203	cholesterol metabolic process
GO:0010951	negative regulation of endopeptidase activity
GO:0030198	extracellular matrix organization
GO:0030900	forebrain development
GO:0030901	midbrain development
GO:0043393	regulation of protein binding
GO:0050885	neuromuscular process controlling balance

Cellular Component

GO:0005634	nucleus
GO:0005886	plasma membrane
GO:0016020	membrane
GO:0016021	integral component of membrane
GO:0070062	extracellular vesicular exosome

Protein Structure and Domains

PDB ID

InterPro

IPR002223 Proteinase inhibitor I2, Kunitz metazoa
IPR008154 Amyloidogenic glycoprotein, extracellular
IPR008155 Amyloidogenic glycoprotein
IPR011178 Amyloidogenic glycoprotein, copper-binding
IPR015849 Amyloidogenic glycoprotein, heparin-binding
IPR019543 Beta-amyloid precursor protein C-terminal
IPR024329 Amyloidogenic glycoprotein, E2 domain

PFAM

PF00014
PF12924
PF02177
PF10515
PF12925

PRINTS

PR00759
PR00203

PIRSF

SMART

SM00131
SM00006

TIGRFAMs

Post-translational Modifications

Modification

Cross-References

SwissProt