InnateDB: Systems Biology of the Innate Immune Response

Homo sapiens Gene: APLP2

Summary

InnateDB Gene

IDBG-76181.6

Last Modified

2014-10-13 [Report errors or provide feedback]

Gene Symbol

APLP2

Gene Name

amyloid beta (A4) precursor-like protein 2

Synonyms

APLP-2; APPH; APPL2; CDEBP

Species

Homo sapiens

Ensembl Gene

ENSG00000084234

Encoded Proteins

IDBP-76183

amyloid beta (A4) precursor-like protein 2

IDBP-76185

amyloid beta (A4) precursor-like protein 2

IDBP-76187

amyloid beta (A4) precursor-like protein 2

IDBP-76189

amyloid beta (A4) precursor-like protein 2

IDBP-596802

amyloid beta (A4) precursor-like protein 2

IDBP-595096

amyloid beta (A4) precursor-like protein 2

IDBP-602306

amyloid beta (A4) precursor-like protein 2

IDBP-585573

amyloid beta (A4) precursor-like protein 2

IDBP-589961

amyloid beta (A4) precursor-like protein 2

IDBP-590595

amyloid beta (A4) precursor-like protein 2

Protein Structure

Useful resources

Stemformatics EHFPI ImmGen

Entrez Gene

Summary

This gene encodes amyloid precursor- like protein 2 (APLP2), which is a member of the APP (amyloid precursor protein) family including APP, APLP1 and APLP2. This protein is ubiquitously expressed. It contains heparin-, copper- and zinc- binding domains at the N-terminus, BPTI/Kunitz inhibitor and E2 domains in the middle region, and transmembrane and intracellular domains at the C-terminus. This protein interacts with major histocompatibility complex (MHC) class I molecules. The synergy of this protein and the APP is required to mediate neuromuscular transmission, spatial learning and synaptic plasticity. This protein has been implicated in the pathogenesis of Alzheimer's disease. Multiple alternatively spliced transcript variants encoding different isoforms have been identified. [provided by RefSeq, Aug 2011]
This gene encodes amyloid precursor- like protein 2 (APLP2), which is a member of the APP (amyloid precursor protein) family including APP, APLP1 and APLP2. This protein is ubiquitously expressed. It contains heparin-, copper- and zinc- binding domains at the N-terminus, BPTI/Kunitz inhibitor and E2 domains in the middle region, and transmembrane and intracellular domains at the C-terminus. This protein interacts with major histocompatibility complex (MHC) class I molecules. The synergy of this protein and the APP is required to mediate neuromuscular transmission, spatial learning and synaptic plasticity. This protein has been implicated in the pathogenesis of Alzheimer\'s disease. Multiple alternatively spliced transcript variants encoding different isoforms have been identified. [provided by RefSeq, Aug 2011]

Gene Information

Type

Protein coding

Genomic Location

Chromosome 11:130069837-130144811

Strand

Forward strand

Band

q24.3

Transcripts

ENST00000263574	ENSP00000263574
ENST00000278756	ENSP00000278756
ENST00000338167	ENSP00000345444
ENST00000345598	ENSP00000263575
ENST00000461918
ENST00000532456
ENST00000533616	ENSP00000434592
ENST00000534761
ENST00000533532
ENST00000530132	ENSP00000433582
ENST00000533195	ENSP00000434059
ENST00000533618
ENST00000533713	ENSP00000434379
ENST00000529235
ENST00000534582	ENSP00000435470
ENST00000527702
ENST00000534001
ENST00000526330
ENST00000529701
ENST00000528499	ENSP00000435914
ENST00000525215
ENST00000529483
ENST00000533860
ENST00000530493
ENST00000525604

Interactions

Number of Interactions

This gene and/or its encoded proteins are associated with 31 experimentally validated interaction(s) in this database.
They are also associated with 7 interaction(s) predicted by orthology.

Experimentally validated
Total	31 [view]
Protein-Protein	31 [view]
Protein-DNA	0
Protein-RNA	0
DNA-DNA	0
RNA-RNA	0
DNA-RNA	0

Predicted by orthology
Total	7 [view]

Gene Ontology

Molecular Function

Accession	GO Term
GO:0003677	DNA binding
GO:0004867	serine-type endopeptidase inhibitor activity
GO:0005515	protein binding
GO:0008201	heparin binding
GO:0042802	identical protein binding
GO:0046914	transition metal ion binding

Biological Process

GO:0001967	suckling behavior
GO:0006878	cellular copper ion homeostasis
GO:0007176	regulation of epidermal growth factor-activated receptor activity
GO:0007186	G-protein coupled receptor signaling pathway
GO:0007617	mating behavior
GO:0007626	locomotory behavior
GO:0008203	cholesterol metabolic process
GO:0010951	negative regulation of endopeptidase activity
GO:0030198	extracellular matrix organization
GO:0030900	forebrain development
GO:0030901	midbrain development
GO:0043393	regulation of protein binding
GO:0050885	neuromuscular process controlling balance

Cellular Component

GO:0005634	nucleus
GO:0005886	plasma membrane
GO:0016020	membrane
GO:0016021	integral component of membrane
GO:0070062	extracellular vesicular exosome

Orthologs

Species

Mus musculus

Bos taurus

Gene ID

Gene Order

ENSMUSG00000031996

View Gene Order

ENSBTAG00000016168

Not yet available

Pathways

NETPATH

NetPath_4

EGFR1 pathway

REACTOME

KEGG

INOH

PID NCI

Cross-References

SwissProt

TrEMBL

E9PK76 Q9UED0

UniProt Splice Variant

Entrez Gene

334

UniGene

Hs.370247

RefSeq

NM_001142276 NM_001142277 NM_001142278 NM_001243299 NM_001642

HUGO

HGNC:598

OMIM

104776

CCDS

CCDS44773 CCDS44774 CCDS44775 CCDS58196 CCDS8486

HPRD

00103

IMGT

EMBL

AB015751 AP001183 AP003041

GenPept

BAA34958

RNA Seq Atlas

102725415 334