Homo sapiens Gene: APLP2 | |||||||||||||||||||||||||||
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Summary | |||||||||||||||||||||||||||
InnateDB Gene | IDBG-76181.6 | ||||||||||||||||||||||||||
Last Modified | 2014-10-13 [Report errors or provide feedback] | ||||||||||||||||||||||||||
Gene Symbol | APLP2 | ||||||||||||||||||||||||||
Gene Name | amyloid beta (A4) precursor-like protein 2 | ||||||||||||||||||||||||||
Synonyms | APLP-2; APPH; APPL2; CDEBP | ||||||||||||||||||||||||||
Species | Homo sapiens | ||||||||||||||||||||||||||
Ensembl Gene | ENSG00000084234 | ||||||||||||||||||||||||||
Encoded Proteins |
amyloid beta (A4) precursor-like protein 2
amyloid beta (A4) precursor-like protein 2
amyloid beta (A4) precursor-like protein 2
amyloid beta (A4) precursor-like protein 2
amyloid beta (A4) precursor-like protein 2
amyloid beta (A4) precursor-like protein 2
amyloid beta (A4) precursor-like protein 2
amyloid beta (A4) precursor-like protein 2
amyloid beta (A4) precursor-like protein 2
amyloid beta (A4) precursor-like protein 2
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Protein Structure | |||||||||||||||||||||||||||
Useful resources | Stemformatics EHFPI ImmGen | ||||||||||||||||||||||||||
Entrez Gene | |||||||||||||||||||||||||||
Summary |
This gene encodes amyloid precursor- like protein 2 (APLP2), which is a member of the APP (amyloid precursor protein) family including APP, APLP1 and APLP2. This protein is ubiquitously expressed. It contains heparin-, copper- and zinc- binding domains at the N-terminus, BPTI/Kunitz inhibitor and E2 domains in the middle region, and transmembrane and intracellular domains at the C-terminus. This protein interacts with major histocompatibility complex (MHC) class I molecules. The synergy of this protein and the APP is required to mediate neuromuscular transmission, spatial learning and synaptic plasticity. This protein has been implicated in the pathogenesis of Alzheimer's disease. Multiple alternatively spliced transcript variants encoding different isoforms have been identified. [provided by RefSeq, Aug 2011] This gene encodes amyloid precursor- like protein 2 (APLP2), which is a member of the APP (amyloid precursor protein) family including APP, APLP1 and APLP2. This protein is ubiquitously expressed. It contains heparin-, copper- and zinc- binding domains at the N-terminus, BPTI/Kunitz inhibitor and E2 domains in the middle region, and transmembrane and intracellular domains at the C-terminus. This protein interacts with major histocompatibility complex (MHC) class I molecules. The synergy of this protein and the APP is required to mediate neuromuscular transmission, spatial learning and synaptic plasticity. This protein has been implicated in the pathogenesis of Alzheimer\'s disease. Multiple alternatively spliced transcript variants encoding different isoforms have been identified. [provided by RefSeq, Aug 2011] |
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Gene Information | |||||||||||||||||||||||||||
Type | Protein coding | ||||||||||||||||||||||||||
Genomic Location | Chromosome 11:130069837-130144811 | ||||||||||||||||||||||||||
Strand | Forward strand | ||||||||||||||||||||||||||
Band | q24.3 | ||||||||||||||||||||||||||
Transcripts | |||||||||||||||||||||||||||
Interactions | |||||||||||||||||||||||||||
Number of Interactions |
This gene and/or its encoded proteins are associated with 31 experimentally validated interaction(s) in this database.
They are also associated with 7 interaction(s) predicted by orthology.
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Gene Ontology | |||||||||||||||||||||||||||
Molecular Function |
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Biological Process |
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Cellular Component |
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Orthologs | |||||||||||||||||||||||||||
Species
Mus musculus
Bos taurus
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Gene ID
Gene Order
Not yet available
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Pathways | |||||||||||||||||||||||||||
NETPATH |
EGFR1 pathway
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REACTOME | |||||||||||||||||||||||||||
KEGG | |||||||||||||||||||||||||||
INOH | |||||||||||||||||||||||||||
PID NCI | |||||||||||||||||||||||||||
Cross-References | |||||||||||||||||||||||||||
SwissProt | |||||||||||||||||||||||||||
TrEMBL | E9PK76 Q9UED0 | ||||||||||||||||||||||||||
UniProt Splice Variant | |||||||||||||||||||||||||||
Entrez Gene | 334 | ||||||||||||||||||||||||||
UniGene | Hs.370247 | ||||||||||||||||||||||||||
RefSeq | NM_001142276 NM_001142277 NM_001142278 NM_001243299 NM_001642 | ||||||||||||||||||||||||||
HUGO | HGNC:598 | ||||||||||||||||||||||||||
OMIM | 104776 | ||||||||||||||||||||||||||
CCDS | CCDS44773 CCDS44774 CCDS44775 CCDS58196 CCDS8486 | ||||||||||||||||||||||||||
HPRD | 00103 | ||||||||||||||||||||||||||
IMGT | |||||||||||||||||||||||||||
EMBL | AB015751 AP001183 AP003041 | ||||||||||||||||||||||||||
GenPept | BAA34958 | ||||||||||||||||||||||||||
RNA Seq Atlas | 102725415 334 | ||||||||||||||||||||||||||