InnateDB: Systems Biology of the Innate Immune Response

Homo sapiens Protein: CARD14

Summary

InnateDB Protein

IDBP-761832.3

Last Modified

2014-10-13 [Report errors or provide feedback]

Gene Symbol

CARD14

Protein Name

Synonyms

Species

Homo sapiens

Ensembl Protein

ENSP00000458715

InnateDB Gene

IDBG-71483 (CARD14)

Protein Structure

UniProt Annotation

Function

Plays a role in signaling mediated by TRAF2, TRAF3 and TRAF6 and protects cells against apoptosis. Activates NF-kappa-B via BCL10 and IKK. Stimulates the phosphorylation of BCL10. {ECO:0000269PubMed:21302310}.

Subcellular Localization

Isoform 1: Cytoplasm.Isoform 2: Cytoplasm.Isoform 3: Cytoplasm.

Disease Associations

Psoriasis 2 (PSORS2) [MIM:602723]: A common, chronic inflammatory disease of the skin with multifactorial etiology. It is characterized by red, scaly plaques usually found on the scalp, elbows and knees. These lesions are caused by abnormal keratinocyte proliferation and infiltration of inflammatory cells into the dermis and epidermis. {ECO:0000269PubMed:22521418, ECO:0000269PubMed:22521419}. Note=Disease susceptibility is associated with variations affecting the gene represented in this entry.Pityriasis rubra pilaris (PRP) [MIM:173200]: A rare, papulosquamous skin disease characterized by the appearance of keratotic follicular papules, well-demarcated salmon-colored erythematous plaques covered with fine powdery scales interspersed with distinct islands of uninvolved skin, and palmoplantar keratoderma. Most cases are sporadic. The rare familial cases show autosomal dominant inheritance with incomplete penetrance and variable expression. Familial PRP usually presents at birth or appears during the first years of life and runs a chronic course. It is characterized by prominent follicular hyperkeratosis, diffuse palmoplantar keratoderma, and erythema. {ECO:0000269PubMed:22703878}. Note=The disease is caused by mutations affecting the gene represented in this entry.

Tissue Specificity

Isoform 1 is detected in placenta and epidermal keratinocytes. Isoform 2 is detected in leukocytes and fetal brain. {ECO:0000269PubMed:22521418}.

Comments

Interactions

Number of Interactions

This gene and/or its encoded proteins are associated with 4 experimentally validated interaction(s) in this database.

Experimentally validated
Total	4 [view]
Protein-Protein	4 [view]
Protein-DNA	0
Protein-RNA	0
DNA-DNA	0
RNA-RNA	0
DNA-RNA	0

Gene Ontology

Molecular Function

Accession	GO Term
GO:0005515	protein binding
GO:0050700	CARD domain binding

Biological Process

GO:0001934	positive regulation of protein phosphorylation
GO:0006915	apoptotic process
GO:0007250	activation of NF-kappaB-inducing kinase activity
GO:0033209	tumor necrosis factor-mediated signaling pathway
GO:0042981	regulation of apoptotic process
GO:0043066	negative regulation of apoptotic process
GO:0051092	positive regulation of NF-kappaB transcription factor activity

Cellular Component

GO:0005622	intracellular
GO:0005737	cytoplasm
GO:0005886	plasma membrane

Protein Structure and Domains

PDB ID

InterPro

IPR001315 CARD domain
IPR001478 PDZ domain
IPR008144 Guanylate kinase-like
IPR011029 Death-like domain
IPR027417 P-loop containing nucleoside triphosphate hydrolase

PFAM

PF00619
PF00595
PF13180

PRINTS

PIRSF

SMART

SM00114
SM00228

TIGRFAMs

Post-translational Modifications

Modification

Cross-References

SwissProt

Q9BXL6